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Titolo:
CHARACTERIZATION OF GENES MODULATED DURING PHEOMELANOGENESIS USING DIFFERENTIAL DISPLAY
Autore:
FURUMURA M; SAKAI C; POTTERF SB; VIEIRA WD; BARSH GS; HEARING VJ;
Indirizzi:
NCI,CELL BIOL LAB,NIH,BLDG 37,ROOM 1B25 BETHESDA MD 20892 NCI,CELL BIOL LAB,NIH BETHESDA MD 20892 STANFORD UNIV,SCH MED,DEPT PEDIAT,HOWARD HUGHES MED INST STANFORD CA 94305
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 95, anno: 1998,
pagine: 7374 - 7378
SICI:
0027-8424(1998)95:13<7374:COGMDP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING-HORMONE; MOUSE AGOUTI GENE; HUMAN HOMOLOG; TYROSINASE GENE; RED HAIR; PROTEIN; EXPRESSION; RECEPTOR; YELLOW; PIGMENTATION;
Keywords:
AGOUTI; MELANOGENESIS; PHEOMELANIN; PIGMENTATION; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Furumura et al., "CHARACTERIZATION OF GENES MODULATED DURING PHEOMELANOGENESIS USING DIFFERENTIAL DISPLAY", Proceedings of the National Academy of Sciences of the United Statesof America, 95(13), 1998, pp. 7374-7378

Abstract

Molecular and biochemical mechanisms that modulate the production of eumelanin or pheomelanin pigments involve the opposing effects of two intercellular signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti signal protein (ASP). ASP is an antagonist of MSH signaling through the melanocyte-specific MSH receptor, although its mechanism(s) of action is controversial. We previously have reported significant down-regulation of all known melanogenic genes during the eumelanin to pheomelanin switch in murine hair follicle melanocytes and in cultured melanocytes treated with recombinant ASP. To identify factors that might be involved in the switch to pheomelanogenesis, we screened ASP-treated melanocytes by using differential display and identified three up-regulated genes: a DNA replication control protein, a basic helix-loop-helix transcription factor, and a novel gene. We have simultaneously identified six down-regulated genes in ASP-treated melanocytes; two of those encode tyrosinase and TRP2, melanogenic genes knownto be down-regulated during pheomelanogenesis, which provide good internal controls for this approach. These results suggest that there arecomplex mechanisms involved in the switch to pheomelanin production, and that these modulated genes might be involved in the pleiotropic changes seen in yellow mice, including the change in coat color.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:59:54