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Titolo:
FAILURE TO REPLICATE AN ASSOCIATION BETWEEN A RARE ALLELE OF A TYROSINE-HYDROXYLASE GENE MICROSATELLITE AND SCHIZOPHRENIA
Autore:
JONSSON EG; GEIJER T; GYLLANDER A; TERENIUS L; SEDVALL GC;
Indirizzi:
KAROLINSKA INST,DEPT CLIN NEUROSCI,PSYCHIAT SECT SE-17176 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT CLIN NEUROSCI,EXPT ALCOHOL & DRUG RES SECT SE-17176 STOCKHOLM SWEDEN
Titolo Testata:
European archives of psychiatry and clinical neuroscience
fascicolo: 2, volume: 248, anno: 1998,
pagine: 61 - 63
SICI:
0940-1334(1998)248:2<61:FTRAAB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Keywords:
SCHIZOPHRENIA; ASSOCIATION STUDY; TYROSINE HYDROXYLASE GENE; CEREBROSPINAL FLUID; HOMOVANILLIC ACID; 3-METHOXY-4-HYDROXYPHENYLGLYCOL; 5-HYDROXYINDOLEACETIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Jonsson et al., "FAILURE TO REPLICATE AN ASSOCIATION BETWEEN A RARE ALLELE OF A TYROSINE-HYDROXYLASE GENE MICROSATELLITE AND SCHIZOPHRENIA", European archives of psychiatry and clinical neuroscience, 248(2), 1998, pp. 61-63

Abstract

An association between schizophrenia and a rare perfect ten-repeat allele, K1(p), of a tetranucleotide microsatellite polymorphism in the tyrosine hydroxylase gene has recently been reported. The rare allele was found only in schizophrenic patients. During treatment with antipsychotic drugs patients with the rare allele displayed lower plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels than those without. We examined Swedish schizophrenic patients (n = 117) and healthy control subjects (n = 76) for the same polymorphism. Incontrast to the previous studies, the K1(p) frequency in patients (4 of 117) tended to be lower than among controls (9 of 76). With all sixalleles (K1(p), K1(i), K2-5) considered there was a significant difference between schizophrenic patients and control subjects. There was no significant difference in HVA and MHPG levels in cerebrospinal fluidfrom a subset (n = 64) of control subjects with and without the rare allele. The discrepant results warrant further investigation of the tyrosine hydroxylase gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:24:42