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Titolo:
PLATELET SEROTONIN TRANSPORTER DEPRESSED CHILDREN AND ADOLESCENTS - H-3-PAROXETINE PLATELET BINDING BEFORE AND AFTER SERTRALINE
Autore:
SALLEE FR; HILAL R; DOUGHERTY D; BEACH K; NESBITT L;
Indirizzi:
CHILDRENS HOSP,MED CTR,3333 BURNETT AVE CINCINNATI OH 45229 MED UNIV S CAROLINA CHARLESTON SC 29425 BAYLOR UNIV,DEPT MED WACO TX 76798 SUNY STONY BROOK,MDPHD PROGRAM STONY BROOK NY 11794 UNIV CINCINNATI,CHILDRENS HOSP,MED CTR CINCINNATI OH 45221 UNIV S ALABAMA,SCH MED,DEPT MED MOBILE AL 36688
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 7, volume: 37, anno: 1998,
pagine: 777 - 784
SICI:
0890-8567(1998)37:7<777:PSTDCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; OBSESSIVE-COMPULSIVE DISORDER; IMIPRAMINE BINDING; 5-HT UPTAKE; H-3-IMIPRAMINE BINDING; HEALTHY-VOLUNTEERS; BLOOD-PLATELETS; FRONTAL-CORTEX; SITES; AGE;
Keywords:
SEROTONIN TRANSPORTER; PLATELET; MAJOR DEPRESSION; H-3-PAROXETINE; SERTRALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
F.R. Sallee et al., "PLATELET SEROTONIN TRANSPORTER DEPRESSED CHILDREN AND ADOLESCENTS - H-3-PAROXETINE PLATELET BINDING BEFORE AND AFTER SERTRALINE", Journal of the American Academy of Child and Adolescent Psychiatry, 37(7), 1998, pp. 777-784

Abstract

Objective: To evaluate serotonin transporter protein (5HTPR) binding in platelets from children and adolescents with major depression (MDD)compared to normal controls using the selective ligand H-3-paroxetine. Method: Children and adolescents with MDD (n = 24) defined by DSM-III-R criteria and normal controls (n = 22) were compared by platelet 5HTPR kinetic analysis with the hypothesis that 5HTPR is reduced in MDD. A subset of MDD subjects (n = 18) continued to participate in a fixed-dose, open-label sertraline trial for 6 weeks followed by drug-free washout and repeated 5HTPR analysis. Results: Sex, prepubertal status, and age had no effect on 5HTPR. Medication-free MDD subjects differed from controls in reduced binding capacity (B-max) (p <.001). Sertraline therapy decreased binding affinity from baseline nonselectively (p <.05), and B-max elevation from baseline was associated with nonresponse and suicide attempt history. Conclusion: Earlier literature in this population is replicated with regard to reduced platelet 5HTPR B,, in MDD. Findings support a continuum of 5HTPR involvement in MDD across the developmental spectrum.

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Documento generato il 22/01/20 alle ore 06:33:54