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Titolo:
PROTECTIVE EFFECT OF CILIARY NEUROTROPHIC FACTOR (CNTF) IN A MODEL OFENDOTOXIC-SHOCK - ACTION MECHANISMS AND ROLE OF CNTF RECEPTOR-ALPHA
Autore:
DEMITRI MT; BENIGNI F; MEAZZA C; ZINETTI M; FRATELLI M; VILLA P; ACHESON A; PANAYOTATOS N; GHEZZI P;
Indirizzi:
95 MONMOUTH COURT ORANGEBURG NY 10962 MARIO NEGRI INST PHARMACOL RES I-20157 MILAN ITALY CNR,CELLULAR & MOL PHARMACOL CTR MILAN ITALY REGENERON PHARMACEUT INC TARRYTOWN NY 10591
Titolo Testata:
Journal of inflammation
fascicolo: 2, volume: 48, anno: 1998,
pagine: 47 - 55
SICI:
1078-7852(1998)48:2<47:PEOCNF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LEUKEMIA INHIBITORY FACTOR; INDUCED PULMONARY-EDEMA; RECOMBINANT HUMAN; MICE; CELLS; RAT; EXPRESSION; CYTOKINES; INJURY;
Keywords:
CILIARY NEUROTROPHIC FACTOR; HYPOTHALAMUS-PITUITARY-ADRENAL AXIS; NEUTROPHIL; NITRIC OXIDE; TUMOR NECROSIS FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Demitri et al., "PROTECTIVE EFFECT OF CILIARY NEUROTROPHIC FACTOR (CNTF) IN A MODEL OFENDOTOXIC-SHOCK - ACTION MECHANISMS AND ROLE OF CNTF RECEPTOR-ALPHA", Journal of inflammation, 48(2), 1998, pp. 47-55

Abstract

Ciliary neurotrophic factor (CNTF) inhibits the production of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-treated mice and protects against LPS lethality when coadministered with its soluble receptor (sCNTFR alpha). Both of these activities are abolished in adrenalectomized (ADX) mice. LPS-induced pulmonary polymorphonuclear neutrophil(PMN) infiltration and nitric oxide (NO) production were also inhibited by CNTF + sCNTFR alpha but not by CNTF alone. sCNTFR alpha: did notalter the clearance or tissue distribution of CNTF. Furthermore, CNTFvariants coadministered with sCNTFR alpha protected against LPS toxicity in a manner related to their affinity for the beta components of CNTFR. Thus inhibition Of TNF production and protection against LPS lethality by CNTF/sCNTFR alpha require an intact hypothalamus-pituitary-adrenal axis (HPAA) and may be mediated by endogenous glucocorticoids. This protective effect is, at least in part, due to the inhibition of PMN infiltration and NO production, and appears to be mediated by cells displaying only beta-receptor subtypes. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:22:09