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Titolo:
PLACENTAL MEMBRANE FATTY-ACID-BINDING PROTEIN PREFERENTIALLY BINDS ARACHIDONIC AND DOCOSAHEXAENOIC ACIDS
Autore:
CAMPBELL FM; GORDON MJ; DUTTAROY AK;
Indirizzi:
ROWETT RES INST ABERDEEN AB21 9SB SCOTLAND ROWETT RES INST ABERDEEN AB21 9SB SCOTLAND
Titolo Testata:
Life sciences (1973)
fascicolo: 4, volume: 63, anno: 1998,
pagine: 235 - 240
SICI:
0024-3205(1998)63:4<235:PMFPPB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; IDENTIFICATION; ALBUMIN;
Keywords:
PLASMA MEMBRANE FATTY ACID-BINDING PROTEIN; FREE FATTY ACIDS; PLACENTA; DOCOSAHEXAENOIC ACID; ARACHIDONIC ACID; PLASMA; FATTY ACID UPTAKE; FABP(PM);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Campbell et al., "PLACENTAL MEMBRANE FATTY-ACID-BINDING PROTEIN PREFERENTIALLY BINDS ARACHIDONIC AND DOCOSAHEXAENOIC ACIDS", Life sciences (1973), 63(4), 1998, pp. 235-240

Abstract

To elucidate further the role of placental membrane fatty acid-binding protein (p-FABP(pm)) in preferential transfer of maternal plasma long chain polyunsaturated fatty acids (LCPUFA) across the human placenta, direct binding of the purified protein with various radiolabelled fatty acids (docosahexaenoic, arachidonic, linoleic and oleic acids) wasinvestigated. Binding of these fatty acids to the protein revealed that p-FABP(pm) had higher affinities and binding capacities for arachidonic and docosahexaenoic acids compared with linoleic and oleic acids. The apparent binding capacities (B-max) values for oleic, linoleic, arachidonic and docosahexaenoic acids were 2.0 +/- 0.14, 2.1 +/- 0.17, 3.5 +/- 0.11, 4.0 +/- 0.10 mol per mol of p-FABP(pm) whereas the apparent dissociation constant (K-d) values were 1.0 +/- 07, 0.73 +/- 0.04,0.45 +/- 0.03 and 0.4 +/- 0.02 mu M, respectively (n=3). In the case of human serum albumin, the K-d and B-max values for all fatty acids were around 1 mu M and 5 mol/mol of protein, respectively. These data provide direct evidence for the role of p-FABP(pm) in preferential sequestration of maternal arachidonic and docosahexaenoic acids by the placenta for transport to the fetus by virtue of its preferential bindingof these fatty acids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:26:50