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Titolo:
ASSOCIATION OF HELICOBACTER-PYLORI INFECTION WITH CARDIOVASCULAR AND CEREBROVASCULAR-DISEASE IN DIABETIC-PATIENTS
Autore:
DELUIS DA; LAHERA M; CANTON R; BOIXEDA D; SANROMAN AL; ALLER R; DELACALLE H;
Indirizzi:
UNIV ALCALA DE HENARES,HOSP RAMON Y CAJAL,DEPT ENDOCRINOL E-28034 MADRID SPAIN UNIV ALCALA DE HENARES,HOSP RAMON Y CAJAL,DEPT MICROBIOL E-28034 MADRID SPAIN UNIV ALCALA DE HENARES,HOSP RAMON Y CAJAL,DEPT GASTROENTEROL E-28034 MADRID SPAIN
Titolo Testata:
Diabetes care
fascicolo: 7, volume: 21, anno: 1998,
pagine: 1129 - 1132
SICI:
0149-5992(1998)21:7<1129:AOHIWC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; MYOCARDIAL-INFARCTION; RISK-FACTORS; HIGH SEROPREVALENCE; CELL COUNT; LIPOPOLYSACCHARIDE; FIBRINOGEN; PNEUMONIAE; POPULATION; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Deluis et al., "ASSOCIATION OF HELICOBACTER-PYLORI INFECTION WITH CARDIOVASCULAR AND CEREBROVASCULAR-DISEASE IN DIABETIC-PATIENTS", Diabetes care, 21(7), 1998, pp. 1129-1132

Abstract

OBJECTIVE - Infection by Helicobacter pylori has been epidemiologically linked to some extradigestive conditions, including ischemic heart disease. Diabetic patients are an at risk population for cardiovascular and thrombo-occlusive cerebral disease. The aim of the study was to examine a possible relationship between H. pylori infection and cardiovascular or cerebrovascular disease in diabetic patients. RESEARCH DESIGN AND METHODS - This was a cross-sectional case-control study with 127 diabetic patients (both IDDM and NIDDM). Special emphasis was placed on the detection of clinical macro- and microvascular complications,cardiovascular risk factors, acute phase reactants, and serological markers of increased cardiovascular disease risk. H. pylori infection was assessed through the determination of specific IgG titers, measuredby a commercial enzyme-linked immunosorbent assay. RESULTS - Coronaryheart disease was more prevalent in diabetic patients with than without H. pylori (odds ratio [OR] 4.07; 95% CI 1.21-13.6; P < 0.05). A history of thrombo-occlusive cerebral disease was also more frequent in H. pylori-positive diabetic patients (OR 4.8; 95% CI 1.24-18.51; P < 0.05). Other complications such as peripheral arteriopathy, advanced nephropathy, neuropathy, or retinopathy were no differently distributed according to serological status. Alterations in the levels of the following acute-phase reactants and blood chemistry determinations were significantly more profound in H. pylori-positive diabetic patients: highfibrinogen (P < 0.05), high erythrocyte sedimentation rate (P < 0.001), high triglycerides (P < 0.001), and low HDL cholesterol (P < 0.001). These values were also more deeply altered in H. pylori-positive diabetic patients with a history of coronary heart disease, thrombo-occlusive cerebral disease, or both, when compared with H. pylori-positive diabetic patients without those complications. CONCLUSIONS - Our data indicate a possible association of H. pylori infection and the development of coronary heart disease, thrombo-occlusive cerebral disease, orboth, in diabetic patients. The importance of this link is highlighted by the possibility of an effective intervention against H, pylori infection.

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Documento generato il 20/01/20 alle ore 16:21:18