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Titolo:
POSTMENOPAUSAL ESTROGENS AND RISK OF MYOCARDIAL-INFARCTION IN DIABETIC WOMEN
Autore:
KAPLAN RC; HECKBERT SR; WEISS NS; WAHL PW; SMITH NL; NEWTON KM; PSATY BM;
Indirizzi:
UNIV WASHINGTON,CARDIOVASC HLTH RES UNIT,SUITE 1360,1730 MINOR AVE SEATTLE WA 98101 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98101 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98101 UNIV WASHINGTON,DEPT MED SEATTLE WA 98101 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98101 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104 GRP HLTH COOPERAT PUGET SOUND,CTR HLTH STUDIES SEATTLE WA 98101
Titolo Testata:
Diabetes care
fascicolo: 7, volume: 21, anno: 1998,
pagine: 1117 - 1121
SICI:
0149-5992(1998)21:7<1117:PEAROM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE MORTALITY; REPLACEMENT THERAPY; GLUCOSE-TOLERANCE; USERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Kaplan et al., "POSTMENOPAUSAL ESTROGENS AND RISK OF MYOCARDIAL-INFARCTION IN DIABETIC WOMEN", Diabetes care, 21(7), 1998, pp. 1117-1121

Abstract

OBJECTIVE-The effect of hormone replacement therapy on the risk of myocardial infarction in diabetic women has not been well studied. We conducted a case-control study of postmenopausal estrogen use and risk of incident myocardial infarction (MI) in pharmacologically treated diabetic women enrolled at Group Health Cooperative of Puget Sound, a large health maintenance organization in the state of Washington. RESEARCH DESIGN AND METHODS-Case subjects (n = 212) were all postmenopausal women with treated diabetes who sustained an incident fatal or nonfatalMI between July 1986 and December 1994. Control subjects (n = 122) were treated diabetic women drawn from a stratified random sample of postmenopausal women without prior MI. Computerized pharmacy data and medical records were used to measure use of estrogens. Cardiovascular risk factors recorded from medical records, computerized pharmacy and laboratory data, and telephone interviews were used as adjustment variables. RESULTS-In this study, 8.5% of case and 13.9% of control subjects were current users of estrogens. The relative risk (RR) of MI for current estrogen users was 0.51 (95% CI 0.22-1.15) relative to never users, adjusted for age, study year, weight, angina, and duration of treated diabetes. Among current estrogen users, risk of MI tended to declinewith each additional year of estrogen use (adjusted RR = 0.78, 95% CI0.56-1.08). Of those studied, 45.3% of case and 37.7% of control subjects were past users of estrogens (adjusted RR = 1.22, 95% CI 0.71-2.09). CONCLUSIONS-This study suggests that use of postmenopausal estrogens does not increase risk of MI in diabetic women and that sustained use may be of benefit.

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Documento generato il 27/11/20 alle ore 04:38:21