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Titolo:
CMV-VIREMIA DURING ALLOGENIC BONE-MARROW TRANSPLANTATION IN PEDIATRIC-PATIENTS - ASSOCIATION WITH SURVIVAL AND GRAFT-VERSUS-HOST DISEASE
Autore:
MATTHESMARTIN S; ABERLE SW; PETERS C; HOLTER W; POPOWKRAUPP T; POTSCHGER U; FRITSCH G; LADENSTEIN R; ROSENMAYER A; DIECKMANN K; GADNER H;
Indirizzi:
ST ANNA CHILDRENS HOSP,KINDERPITALGASSE 6 A-1090 VIENNA AUSTRIA UNIV VIENNA,INST VIROL A-1095 VIENNA AUSTRIA CHILDRENS CANC RES INST VIENNA AUSTRIA AUSTRIAN BONE MARROW DONOR REGISTRY VIENNA AUSTRIA UNIV VIENNA,DEPT RADIOTHERAPY & BIOL VIENNA AUSTRIA
Titolo Testata:
Bone marrow transplantation
, volume: 21, anno: 1998, supplemento:, 2
pagine: 53 - 56
SICI:
0268-3369(1998)21:<53:CDABTI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOMEGALOVIRUS-INFECTION; RECIPIENTS;
Keywords:
CYTOMEGALOVIRUS; PCR; CHILDREN; GRAFT-VERSUS-HOST DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
S. Matthesmartin et al., "CMV-VIREMIA DURING ALLOGENIC BONE-MARROW TRANSPLANTATION IN PEDIATRIC-PATIENTS - ASSOCIATION WITH SURVIVAL AND GRAFT-VERSUS-HOST DISEASE", Bone marrow transplantation, 21, 1998, pp. 53-56

Abstract

Sixty-one consecutive paediatric patients undergoing allogenic bone marrow transplantation (BMT) were screened prospectively for cytomegalovirus (CMV)viraemia viraemia by PCR, Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100, Although only four of them had evidence of CMV-disease, there was a significant difference in the incidence of acute Graft ver sus Host Disease (GVHD) grade III-IV (75% vs 15.5%), liver-involvement (68% vs 13%) and the incidence of chronic GVHD (83% vs 13.8%) between CMV-PCR-positive and CMV-PCR-negative patients. Transplant-related mortality (TRM) was 43.7% in the CMV-PCR-positive group versus 13% in patients which had noevidence for CMV-viraemia, In all but one cases mortality in CMV-PCR positive patients was GVHD-associated, Pre-emptive therapy with gancyclovir in case of CMV-viraemia seemed to have no impact on incidence and severity of GVHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:38:36