Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEVELOPMENTAL-CHANGES IN HETEROPLASMY LEVEL AND MITOCHONDRIAL GENE-EXPRESSION IN A DROSOPHILA-SUBOBSCURA MITOCHONDRIAL DELETION MUTANT
Autore:
PETIT N; TOURAILLE S; DEBISE R; MOREL F; RENOUX M; LECHER P; ALZIARI S;
Indirizzi:
UNIV CLERMONT FERRAND,EQUIPE GENOME MITOCHONDRIAL,CNRS,UMR 6547 F-63177 AUBIERE FRANCE UNIV CLERMONT FERRAND,EQUIPE GENOME MITOCHONDRIAL,CNRS,UMR 6547 F-63177 AUBIERE FRANCE
Titolo Testata:
Current genetics
fascicolo: 5, volume: 33, anno: 1998,
pagine: 330 - 339
SICI:
0172-8083(1998)33:5<330:DIHLAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-LOOP REGION; DNA; MTDNA; GENOMES; MODEL; ORGANIZATION; DUPLICATION; REPLICATION; MYOPATHIES; PODOSPORA;
Keywords:
MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION; HETEROPLASMY; DROSOPHILA SUBOBSCURA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N. Petit et al., "DEVELOPMENTAL-CHANGES IN HETEROPLASMY LEVEL AND MITOCHONDRIAL GENE-EXPRESSION IN A DROSOPHILA-SUBOBSCURA MITOCHONDRIAL DELETION MUTANT", Current genetics, 33(5), 1998, pp. 330-339

Abstract

Eighty percent of DNA molecules are deleted in the mitochondrial population of an adult mutant strain of D. subobscura. Both intact and deleted genomes are autonomous monomers. The heteroplasmy level, which islower in germ tissue, increases from the oocytes (60%) to the third larval instar (83%), and is then maintained throughout the life of the fly. The mtDNA/nuclear DNA ratio is on average two-times greater in the heteroplasmic strain than in the wild-type strain, irrespective of the stage, but the cellular content of mitochondria is elevated only inthe embryos and pupae of the mutant strain. The steady state concentrations (SSCs) of the transcripts affected by the deletion are greatly reduced at the larval and adult stages, and less so at the pupal stageof the mutant strain compared with the wild-type. The SSCs of these transcripts are identical in the two strains at the embryonic stage. The Fusion transcript, indicating that the deleted genome is expressed, was detected at all stages. The mechanisms involved in the changes in the heteroplasmy level during the course of development and in its maintenance from the third larval instar onwards are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:17:34