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Titolo:
INHALATION OF AEROSOLIZED SURFACTANT (EXOSURF(R)) TO NEONATES TREATEDWITH NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE
Autore:
ARROE M; PEDERSENBJERGAARD L; ALBERTSEN P; BODE S; GREISEN G; JONSBO F; LUNDSTROM K; STRUCK J; WESTERGAARD M; PEITERSEN B;
Indirizzi:
RIGSHOSP,DEPT NEONATOL,BLEGDAMSVEJ 9 DK-2100 COPENHAGEN DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT PAEDIAT DK-2650 HVIDOVRE DENMARK
Titolo Testata:
Prenatal. neonatal med.
fascicolo: 3, volume: 3, anno: 1998,
pagine: 346 - 352
SICI:
1359-8635(1998)3:3<346:IOAS(T>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; SYNTHETIC SURFACTANT; CONTROLLED TRIAL; WEEKS GESTATION; THERAPY; LUNG; NEWBORNS; EFFICACY;
Keywords:
AEROSOLIZED SURFACTANT; RESPIRATORY DISTRESS; NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE; NEONATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Arroe et al., "INHALATION OF AEROSOLIZED SURFACTANT (EXOSURF(R)) TO NEONATES TREATEDWITH NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE", Prenatal. neonatal med., 3(3), 1998, pp. 346-352

Abstract

The aim of this pilot study was to estimate whether inhalation of aerosolized synthetic surfactant in different dosages would improve systemic oxygenation in infants with mild to moderate respiratory distress syndrome treated with nasal continuous positive airway pressure (CPAP). Twenty-two neonates with respiratory distress treated with nasal CPAP at a pressure of 4-8 cmH(2)O with fraction of inspired oxygen (FiO(2)) 0.3-0.6 and arterio-alveolar oxygen tension ratio (a/A-ratio) > 0.2were treated with aerosolized surfactant (Exosurf(R)) in a closed nasal CPAP system. The infants were given two inhalations with 1 + 1, 2 2, 4 + 4, and 8 + 8 vials of Exosurf with 6-h interval. The gestational age was 23 3/7 to 36 5/7 weeks and the birth weight 540-2721 g. Thedelivered dose of aerosolized surfactant was estimated to be between half and four times the amount of surfactant in a newborn infant. Eight infants were intubated and mechanically ventilated either during or after the study period. Four of these infants were treated with additional endotracheal surfactant, but only one infant improved so much on this treatment that persistent surfactant deficiency could be assumed. Overall, surfactant inhalation did not improve the a/A-ratio. There was no significant dependency between the a/A-ratio response and the dose of Exosurf, the gestational age or the a/A-ratio before the first inhalation in the study group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:25:41