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Titolo:
MODIFIABLE RISK-FACTORS FOR INCIDENT HEART-FAILURE IN THE CORONARY-ARTERY SURGERY STUDY
Autore:
HOFFMAN RM; PSATY BM; KRONMAL RA;
Indirizzi:
ARIZONA HLTH SCI CTR,ROOM 6335,1501 N CAMPBELL AVE TUCSON AZ 85724 VET AFFAIRS MED CTR,MED SERV SEATTLE WA 98108 UNIV WASHINGTON,DEPT MED SEATTLE WA 00000 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195
Titolo Testata:
Archives of internal medicine
fascicolo: 4, volume: 154, anno: 1994,
pagine: 417 - 423
SICI:
0003-9926(1994)154:4<417:MRFIHI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; BYPASS-SURGERY; DISEASE; MORTALITY; OBESITY; EPIDEMIOLOGY; POPULATION; ENALAPRIL; PROGNOSIS; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Hoffman et al., "MODIFIABLE RISK-FACTORS FOR INCIDENT HEART-FAILURE IN THE CORONARY-ARTERY SURGERY STUDY", Archives of internal medicine, 154(4), 1994, pp. 417-423

Abstract

Background: Even with aggressive treatment, heart failure is associated with a substantial morbidity and mortality. This poor prognosis hasled to increasing interest in primary prevention, and the identification of modifiable risk factors. Our objective was to determine whethermodifiable cardiovascular risk factors, including systolic and diastolic blood pressure, fasting glucose level, cholesterol level, weight, and smoking, were independent risk factors for heart failure in patients with anatomically confirmed coronary artery disease. Methods: We studied all patients with documented coronary artery disease eligible for the multicenter, randomized-controlled Coronary Artery Surgery Study. After excluding 79 prevalent cases, we identified incident cases of heart failure using hospital discharge abstracts, mortality records, or self-reported follow-up questionnaires. Criteria for self-reported cases were treatment with digitalis and/or furosemide plus two or more heart failure symptoms, including dyspnea on exertion, orthopnea, paroxysmal nocturnal dyspnea, or edema. Cox regression analysis was used to estimate adjusted relative risks. Results: At 12-year follow-up, thecumulative incidence of heart failure was 20.6%. Smoking (relative risk, 1.47) and weight (relative risk, 1.15/10 kg) were independently associated with incident heart failure. Myocardial infarction during follow-up, age, female sex, and baseline left ventricular dysfunction were also risk factors for heart failure. Conclusions: Patients with stable coronary artery disease are at high risk for developing heart failure, especially following myocardial infarction. However, interventionsaimed at smoking cessation and weight reduction may prevent clinical heart failure in these patients.

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Documento generato il 26/11/20 alle ore 19:11:48