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Titolo:
IMPLICATIONS OF BRAIN IMAGING FOR THE MANAGEMENT OF SCHIZOPHRENIA
Autore:
NYBERG S; NILSSON U; OKUBO Y; HALLDIN C; FARDE L;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT CLIN NEUROSCI,SECT PSYCHIAT S-17176 STOCKHOLM SWEDEN
Titolo Testata:
International clinical psychopharmacology
, volume: 13, anno: 1998, supplemento:, 3
pagine: 15 - 20
SICI:
0268-1315(1998)13:<15:IOBIFT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR OCCUPANCY; C-11 RACLOPRIDE BINDING; LIVING HUMAN-BRAIN; ANTIPSYCHOTIC-DRUGS; SCHIZOAFFECTIVE DISORDER; TREATED PATIENTS; DOUBLE-BLIND; PET; HALOPERIDOL; RISPERIDONE;
Keywords:
ANTIPSYCHOTIC DRUGS; DOPAMINE D-2-RECEPTOR OCCUPANCY; SEROTONIN (5-HT2A) RECEPTOR OCCUPANCY; EXTRAPYRAMIDAL SYMPTOMS; POSITRON EMISSION TOMOGRAPHY; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S. Nyberg et al., "IMPLICATIONS OF BRAIN IMAGING FOR THE MANAGEMENT OF SCHIZOPHRENIA", International clinical psychopharmacology, 13, 1998, pp. 15-20

Abstract

Positron emission tomography (PET) can be used to explore relationships between central neuroreceptor occupancy, psychotropic drug blood levels and clinical effects. Treatment with conventional neuroleptics induces high (70-90%) dopamine (D-2)-receptor occupancy. The risk of extrapyramidal side effects increases at D-2-receptor occupancies above 80%. Standard doses of clozapine induced a low (20-67%) D-2-receptor occupancy; but very high (85-90%) 5-hydroxytryptamine (5-HT2A) receptor occupancy. The novel antipsychotics risperidone and olanzapine inducedhigh occupancy of both D-2 and 5-HT2A receptors at suggested standarddoses. The occurrence of extrapyramidal side effects in some patientsin the higher dose ranges does not support the view that 5-HT2A-receptor occupancy completely prevents the development of extrapyramidal side effects. These results emphasize the need for further exploration of the low dose ranges of risperidone and olanzapine. A preliminary analysis of an ongoing PET study showed that a schizophrenic patient treated with sertindole at 20 mg/day had a D-2-receptor occupancy of below70%3. Further studies are needed to show whether sertindole is the first new antipsychotic that induces low occupancy in the clinical dose range, suggesting a mechanism of action distinct from that of classical neuroleptics and analogous to that of clozapine. Int Clin Psychopharmarol 13(suppl.3):S15-S20 (C) 1998 Lippicott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 14:00:34