Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HETEROGENEITY OF APOLIPOPROTEIN B-100-CONTAINING LIPOPROTEINS - WHAT WE HAVE LEARNT FROM KINETIC-STUDIES
Autore:
MILLAR JS; PACKARD CJ;
Indirizzi:
UNIV GLASGOW,GLASGOW ROYAL INFIRM,UNIV NHS TRUST,DEPT PATHOL BIOCHEM,4TH FLOOR GLASGOW G31 2ER LANARK SCOTLAND
Titolo Testata:
Current opinion in lipidology
fascicolo: 3, volume: 9, anno: 1998,
pagine: 197 - 202
SICI:
0957-9672(1998)9:3<197:HOABL->2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
APO-B SECRETION; HEPG2 CELLS; TRIGLYCERIDE; PRECURSORS; BINDING; LDL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Millar e C.J. Packard, "HETEROGENEITY OF APOLIPOPROTEIN B-100-CONTAINING LIPOPROTEINS - WHAT WE HAVE LEARNT FROM KINETIC-STUDIES", Current opinion in lipidology, 9(3), 1998, pp. 197-202

Abstract

Apolipoprotein B-100-containing lipoprotein assembly is dependent on the successive addition of triglyceride by microsomal transfer protein. Assembly may end at this point and the lipoprotein secreted or it may continue with the bulk addition of triglyceride by an unknown transfer process. These steps are independently regulated and result in the secretion of a spectrum of apolipoprotein B-100-containing particles. The production of small, dense LDL is determined by the type of VLDL secreted by the liver, Large, triglyceride-rich VLDL1 results in the formation of small, dense LDL through triglyceride exchange and subsequent hydrolysis. Small, dense LDL are cleared from plasma relatively slowly and tend to accumulate in the circulation where they exert their atherogenic effects. Curr Opin Lipidol 9:197-202. (C) 1998 Lippincott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:18:17