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Titolo:
LACK OF ASSOCIATION BETWEEN THE DOPAMINE D2 RECEPTOR GENE ALLELE DRD2-ASTERISK-A1 AND CIGARETTE-SMOKING IN A UNITED-KINGDOM POPULATION
Autore:
SINGLETON AB; THOMSON JR; MORRIS CM; COURT JA; LLOYD S; CHOLERTON S;
Indirizzi:
UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHARMACOL SCI NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHARMACOL SCI NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Pharmacogenetics
fascicolo: 2, volume: 8, anno: 1998,
pagine: 125 - 128
SICI:
0960-314X(1998)8:2<125:LOABTD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINE DEPENDENCE; DRD2 GENE; ALCOHOLISM; VULNERABILITY; OBESITY; ABUSE; RFLP;
Keywords:
DRD2 TAQI A POLYMORPHISM; CIGARETTE SMOKING; MOTIVES; QUESTIONNAIRE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Singleton et al., "LACK OF ASSOCIATION BETWEEN THE DOPAMINE D2 RECEPTOR GENE ALLELE DRD2-ASTERISK-A1 AND CIGARETTE-SMOKING IN A UNITED-KINGDOM POPULATION", Pharmacogenetics, 8(2), 1998, pp. 125-128

Abstract

The dopamine D2 receptor gene contains a TaqI repeat fragment length polymorphism creating two alleles DRD2A1 and DRD2*A2, It has been previously suggested that the lesser allele, DRD2A1, is more prevalent in individuals who are susceptible to impulsive/addictive/compulsive behaviour, for example, alcoholics, polysubstance abusers and tobacco smokers, We genotyped a series of 104 smokers and 117 non smokers and compared the allele frequencies between the groups, A subset (n = 87) ofthe smoking population also completed the Classification of Smoking by Motives questionnaire and were given scores for five criteria that drive smoking: automatic, dependence, sedative, stimulant and indulgence, Another subset (n = 52) completed the Fagerstrom Tolerance Questionnaire and were given scores for nicotine dependence, We did not find any increase in allele A1 frequency when comparing smokers to non smokers. Furthermore, neither measure of dependence was affected by possession of the A1 allele; the only difference between DRD2A1 bearing and DRD2A2 homozygous individuals in terms of smoking motives was found in the scores for indulgence; the former having a moderately reduced score (by 17%, p < 0.05). We conclude that, in the individuals studied, the dopamine D2 receptor TaqI locus does not affect the drive to smoke, This may be caused by the locus being unrelated to impulsive/addictive/compulsive behaviour, the polymorphism being in linkage disequilibrium with another distinct locus or, alternatively, smoking may represent a behaviour that is not directly comparable to impulsive/addictive/compulsive behaviours previously associated with the DRD2A1 allele. Pharmacogenetics 8: 125-128 (C) 1998 Lippincott-Raven Publishers.

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Documento generato il 04/04/20 alle ore 14:05:09