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Titolo:
E-CADHERIN EXPRESSION IN THYMOMAS
Autore:
YANG WI; YANG KM; HONG SW; KIM KD;
Indirizzi:
YONSEI UNIV,COLL MED,DEPT PATHOL,CPO BOX 8044 SEOUL 120752 SOUTH KOREA YONSEI WONJU UNIV,COLL MED,DEPT PATHOL WONJU SOUTH KOREA YONSEI UNIV,COLL MED,DEPT THORAC & CARDIOVASC SURG SEOUL SOUTH KOREA
Titolo Testata:
Yonsei medical journal
fascicolo: 1, volume: 39, anno: 1998,
pagine: 37 - 44
SICI:
0513-5796(1998)39:1<37:EEIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC EPITHELIAL TUMORS; CELL-ADHESION; CLINICAL STAGES; CARCINOMA; FEATURES; PROTEIN; P53; INVASION; SURVIVAL; CANCER;
Keywords:
E-CADHERIN; THYMOMAS; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W.I. Yang et al., "E-CADHERIN EXPRESSION IN THYMOMAS", Yonsei medical journal, 39(1), 1998, pp. 37-44

Abstract

For the purpose of investigating the pattern of E-cadherin (E-CD) expression in thymomas, 72 cases were immunostained using monoclonal antibody (HECD-1) and microwave-enhanced immunohistochemical method on formalin-fixed, paraffin-embedded tissue sections. The thymomas were classified according to modified Muller-Hermelink classification. The spindle-shaped, medullary type tumor epithelial cells in medullary (3 cases) and composite type (20 cases) thymonas rarely expressed E-CD exceptin focal areas showing microcystic change observed in 8 cares. Meanwhile, the cohesive epithelioid tumor cells in every case of well-differentiated thymic carcinomas (WDTC) (29 cases) expressed E-CD. The epithelial cells in cortical type (13 cases) expressed stronger E-CD compared with those of organoid type (7 cases). In cases of WDTC admired with cortical type, we observed increasing expression of E-CD as the tumor epithelium forms cohesive sheets. We could not find any loss of E-CDexpression in invasive foci of the 11 cases of high-staged WDTC examined. Since the results of our study show a strong correlation between E-CD expression and epithelioid morphology of the tumor, E-CD seems toplay a major role as a morpho-regulatory factor rather than as a suppressor of invasion in organotypic thymomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:32:45