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Titolo:
IMMUNOREACTIVITY OF ANDROGEN RECEPTOR PROTEIN IN SEXUALLY DIMORPHIC SPINAL MOTONUCLEUS IN NEONATAL MALE RATS
Autore:
HAN SW; RHA KH; LEE WT; MAH SY; CHOI HK; CHOI SK;
Indirizzi:
YONSEI UNIV,COLL MED,DEPT UROL,CPO 8044 SEOUL 120752 SOUTH KOREA YONSEI UNIV,COLL MED,DEPT UROL SEOUL 120752 SOUTH KOREA YONSEI UNIV,COLL MED,DEPT ANAT SEOUL 120752 SOUTH KOREA
Titolo Testata:
Yonsei medical journal
fascicolo: 1, volume: 39, anno: 1998,
pagine: 13 - 19
SICI:
0513-5796(1998)39:1<13:IOARPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING NEUROMUSCULAR SYSTEM; TESTICULAR DESCENT; HORMONAL-CONTROL; PREOPTIC AREA; CORD; GUBERNACULUM; NUCLEUS; MOTONEURONS; BULBOCAVERNOSUS; MASCULINIZATION;
Keywords:
GENITOFEMORAL NERVE; SPINAL MOTONUCLEUS; NEONATE; ANDROGEN RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Han et al., "IMMUNOREACTIVITY OF ANDROGEN RECEPTOR PROTEIN IN SEXUALLY DIMORPHIC SPINAL MOTONUCLEUS IN NEONATAL MALE RATS", Yonsei medical journal, 39(1), 1998, pp. 13-19

Abstract

The spinal motonucleus of the genitofemoral nerve regulating scrotal temperature can also be related to prenatal and neonatal testicular descent by gubernacular change in rats, and a sexually dimorphic-like bulbocavernosus/dorsolateral motonucleus. There is a hypothesis that neonatal androgen affects these motonuclei, and induces development of sexual organs through neural stimulation. Until now, the accumulation ofisotope-labelled androgen and the immunoreactivity of androgen receptor protein in each sexually-dimorphic spinal motonucleus have been revealed in adult rats but they have not been established in rats during neonatal periods. To investigate the presence of the androgen receptorin spinal sexually-dimorphic motonuclei in the neonatal period we evaluated the androgen receptor immunoreactivity of these motonuclei. In Sprague-Dawley male rats, the lumbar spinal cords were resected at postnatal days 3, 10 and 30 and stained immunohistochemically using polyclonal antibody of androgen receptor protein. The immunoreactivity of androgen receptor protein was observed in the cells of the genitofemoral motonucleus from the 13th thoracic to the 2nd lumbar spinal card andthe bulbocavernosus/dorsolateral motonucleus was observed from the 4th to 5th lumbar spinal cord in all age groups. The proportional areas of both motonuclei at days 3 and 10 on cross-section were larger than at day 30. The motonuclei at days 3 and 10 were similar in all age groups. With the above results, the presence of androgen receptor proteinwas confirmed in the genitofemoral and bulbocavernosus/dorsolateral motonucleus from neonate to day 30. The larger proportional area of these motonuclei in neonates may indicate an active role for these motonuclei during the neonatal period. Although the immunoreactivity does not directly imply the presence of a functional receptor, neonatal androgen could be responsible for the development of sexual organs through the spinal motonucleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 16:50:05