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Titolo:
CIRCADIAN-RHYTHM-DEPENDENT EFFECTS OF L-N-G-NITROARGININE METHYL-ESTER (L-NAME) ON MORPHINE-INDUCED ANALGESIA
Autore:
GUNEY HZ; GORGUN CZ; TUNCTAN B; ULUDAG O; HODOGLUGIL U; ABACIOGLU N; ZENGIL H;
Indirizzi:
GAZI UNIV,FAC MED,DEPT PHARMACOL,POB 49 TR-06502 ANKARA TURKEY
Titolo Testata:
Chronobiology international
fascicolo: 3, volume: 15, anno: 1998,
pagine: 283 - 289
SICI:
0742-0528(1998)15:3<283:CEOLM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS NITRIC-OXIDE; RAT PINEAL-GLAND; ANTINOCICEPTIVE ACTIVITY; GUANYLATE-CYCLASE; ADENYLATE-CYCLASE; MOUSE; SYSTEM; STIMULATION; MODULATION; INHIBITORS;
Keywords:
MORPHINE; L-NAME; TEMPORAL VARIATIONS; MOUSE; HOT-PLATE TEST; CIRCADIAN RHYTHM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
H.Z. Guney et al., "CIRCADIAN-RHYTHM-DEPENDENT EFFECTS OF L-N-G-NITROARGININE METHYL-ESTER (L-NAME) ON MORPHINE-INDUCED ANALGESIA", Chronobiology international, 15(3), 1998, pp. 283-289

Abstract

Circadian changes in the interactions between L-N-G-nitroarginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, and morphine-induced antinociception were investigated by the mouse hot-plate test. Both the basal pain sensitivity and morphine-induced analgesia undergo significant 24h variations. L-NAME (40 mg/kg, ip) alone did not show any antinociceptive activity, but potentiated morphine-induced analgesia when combined with morphine at all injection times. In terms of percentage absolute potentiation (%AP), L-NAME dramatically augmented the analgesic effect of morphine in the late dark period at 19 hoursafter lights on (HALO). It is concluded that nitric oxide (NO) is involved in the modulation of the analgesic effect of morphine; thus, theL-NAME and morphine combination might be beneficial in alleviating pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:29:33