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Titolo:
DIFFERENTIAL EXPRESSION OF THE ALPHA-9 NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT IN NEONATAL AND ADULT COCHLEAR HAIR-CELLS
Autore:
SIMMONS DD; MORLEY BJ;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90095 BOYS TOWN NATL RES HOSP,NEUROCHEM LAB OMAHA NE 68131
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 56, anno: 1998,
pagine: 287 - 292
SICI:
0169-328X(1998)56:1-2<287:DEOTAN>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; EFFERENT INNERVATION; OLIVOCOCHLEAR INNERVATION; POSTNATAL MATURATION; RAT COCHLEA; INNER;
Keywords:
SYNAPTOGENESIS; EFFERENT; OLIVOCOCHLEAR; HYBRIDIZATION, IN SITU; ORGAN OF CORTI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.D. Simmons e B.J. Morley, "DIFFERENTIAL EXPRESSION OF THE ALPHA-9 NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT IN NEONATAL AND ADULT COCHLEAR HAIR-CELLS", Molecular brain research, 56(1-2), 1998, pp. 287-292

Abstract

The expression of the alpha 9 nicotinic acetylcholine receptor (nAChR) subunit was investigated in perinatal and adult rat cochleae using [S-35] labeled cRNA in situ hybridization techniques. In the adult, alpha 9 expression showed both longitudinal and radial gradients. The highest expression occurs over outer hair cells (OHCs) in basal regions, and particularly, OHCs in row 1. In contrast, expression over IHCs is lowest in basal regions and highest in apical regions. During embryonic and postnatal ages, the pattern of alpha 9 expression differs. Expression of alpha 9 was nearly equivalent over IHCs and OHCs. Additionally, the greater epithelial ridge, which is adjacent to IHCs before birth, shows a high level of alpha 9 expression. These data are consistentwith current models of efferent synaptogenesis and suggest that the expression of the alpha 9 nAChR may be influenced by the arrival of efferent axons. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:53:01