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Titolo:
A REVIEW OF PRACTICAL TECHNIQUES FOR THE DIAGNOSIS OF MALARIA
Autore:
MAKLER MT; PALMER CJ; AGER AL;
Indirizzi:
FLOW INC,6127 SW CORBETT PORTLAND OR 97201 UNIV MIAMI,SCH MED,CTR DIS PREVENT MIAMI FL 33136 UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL MIAMI FL 33136
Titolo Testata:
Annals of tropical medicine and parasitology
fascicolo: 4, volume: 92, anno: 1998,
pagine: 419 - 433
SICI:
0003-4983(1998)92:4<419:AROPTF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; PLASMODIUM-FALCIPARUM INFECTION; MANUAL PARASIGHT(TM)-F TEST; ANTIGEN-CAPTURE ASSAY; LACTATE-DEHYDROGENASE; FLUORESCENCE MICROSCOPY; LABORATORY DIAGNOSIS; DNA DIAGNOSIS; FIELD; BENZOTHIOCARBOXYPURINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Makler et al., "A REVIEW OF PRACTICAL TECHNIQUES FOR THE DIAGNOSIS OF MALARIA", Annals of tropical medicine and parasitology, 92(4), 1998, pp. 419-433

Abstract

Malaria is a global health problem, responsible for nearly 3 million deaths each year, and on the increase worldwide. Improvements in malaria diagnostics should facilitate the identification of individuals infected with the malarial parasites and the treatment of such cases withappropriate drugs. Both traditional and contemporary methods for malaria diagnosis are the subjects of the present review. Traditional diagnosis, based on the examination of Giemsa-stained thick and thin bloodsmears under a microscope, is inappropriate for many areas because there are insufficient microscopes and/or trained microscopists to read and interpret the slides. Such traditional methods are discussed in the context of parasite quantification. Newer, more advanced malaria diagnostics are now available and the relative merits of methods based onfluorescent microscopy or the detection of nucleic acid (including PC,R) are described, including comparisons of costs. Fluorescent microscopy a.nd nucleic-acid techniques both require skills and equipment which are not universally available in many malaria-endemic countries. Recently introduced diagnostic tests based on immune-assays solve this problem since they are easy to run and interpret, and do not require complex equipment or technical support. They are also rapid (< 10 min/test), cost-effective and at least as sensitive as traditional microscopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:37:10