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Titolo:
EFFECTS OF SELECTIVE INHIBITORS OF NEURONAL NITRIC-OXIDE SYNTHASE ON CARRAGEENAN-INDUCED MECHANICAL AND THERMAL HYPERALGESIA
Autore:
HANDY RLC; MOORE PK;
Indirizzi:
UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,MANRESA RD LONDONSW3 6LX ENGLAND UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP LONDON SW3 6LX ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 1, volume: 37, anno: 1998,
pagine: 37 - 43
SICI:
0028-3908(1998)37:1<37:EOSION>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-(2-TRIFLUOROMETHYLPHENYL) IMIDAZOLE TRIM; EXHIBITS ANTINOCICEPTIVE ACTIVITY; 7-NITRO INDAZOLE; PARTIAL AGONIST; GLYCINE SITE; IN-VITRO; INFLAMMATION; MOUSE; RATS; PAIN;
Keywords:
HYPERALGESIA; CARRAGEENAN; NITRIC OXIDE SYNTHASE; 7-NITROINDAZOLE; 1-(2-TRIFLUOROMETHYLPHENYL) IMIDAZOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R.L.C. Handy e P.K. Moore, "EFFECTS OF SELECTIVE INHIBITORS OF NEURONAL NITRIC-OXIDE SYNTHASE ON CARRAGEENAN-INDUCED MECHANICAL AND THERMAL HYPERALGESIA", Neuropharmacology, 37(1), 1998, pp. 37-43

Abstract

The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed using mechanical and thermal noxious stimuli) andoedema formation following intraplantar injection of carrageenan (150mu l, 2% w v(-1)) in the rat was determined. For this purpose, NOS inhibitors including L-NG nitro-arginine methyl ester (L-NAME; isoform non-selective NOS inhibitor), 7-nitroindazole (7-NI) and 1-(2-trifluoromethylphenyl) imidazole (TRIM; both relatively selective inhibitors ofneuronal NOS) were used. Mechanical/thermal nociceptive threshold values and hindpaw weight were recorded prior to and 3 h after administration of carrageenan. NOS inhibitors (5-25 mg kg(-1), i.p.) were administered 2.5 h after carrageenan. L-NAME, 7-NI and TRIM inhibited carrageenan-induced mechanical and thermal hyperalgesia. Calculated ED,, values (mu mol kg(-1), i.p.) were 63.4, 96.2 and 92.7 (mechanical) and 42.2, 53.9 and 62.1 (thermal), respectively. None of the drugs affected pain perception in the non-injected hindpaw or carrageenan-induced hindpaw weight gain. Thus, 7-NI and TRIM, at doses previously reported not to influence cardiovascular haemodynamics, inhibit hyperalgesia in the rat regardless of the type of noxious stimulus employed. Accordingly, selective inhibitors of neuronal NOS may prove useful for the treatment of prolonged pain in man. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:31:56