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Titolo:
IN-VITRO AND IN-VIVO EFFECTS OF NITRIC-OXIDE SYNTHASE INHIBITORS AND NITRIC-OXIDE INACTIVATORS ON THE SOUTH-AMERICAN OPOSSUM ILEOCOLONIC JUNCTION
Autore:
MATSUDA NM; FEITOSA RL; LEMOS MC; DEOLIVEIRA RB; BALLEJO G;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL,3900 AVE BANDEIRANTES BR-14049900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL BR-14049900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT CLIN MED BR-14049900 RIBEIRAO PRET SP BRAZIL
Titolo Testata:
Neurogastroenterology and motility
fascicolo: 3, volume: 10, anno: 1998,
pagine: 245 - 252
SICI:
1350-1925(1998)10:3<245:IAIEON>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER ESOPHAGEAL SPHINCTER; NONADRENERGIC NONCHOLINERGIC MECHANISMS; CYCLASE ACTIVATING PEPTIDE; RAT GASTRIC FUNDUS; NITRERGIC NEUROTRANSMITTER; SUPEROXIDE-DISMUTASE; ANOCOCCYGEUS MUSCLE; ILEOCECAL JUNCTION; S-NITROSOTHIOLS; RELAXATIONS;
Keywords:
CIRCULAR MUSCLE RELAXATIONS; ILEOCOLONIC JUNCTION; NITRIC OXIDE; NITRIC OXIDE INACTIVATORS; NITRIC OXIDE SYNTHASE INHIBITORS; NONADRENERGIC NONCHOLINERGIC NERVES; SOUTH AMERICAN OPOSSUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
N.M. Matsuda et al., "IN-VITRO AND IN-VIVO EFFECTS OF NITRIC-OXIDE SYNTHASE INHIBITORS AND NITRIC-OXIDE INACTIVATORS ON THE SOUTH-AMERICAN OPOSSUM ILEOCOLONIC JUNCTION", Neurogastroenterology and motility, 10(3), 1998, pp. 245-252

Abstract

The potential role of nitrergic nerves in the regulation of the SouthAmerican (SA) opossum ileocolonic junction (ICJ) function was investigated. In vitro, the effects of nitric oxide (NO) synthase inhibitors and NO inactivators on the non-adrenergic noncholinergic (NANC) nerve-mediated relaxations of the circular muscle of the SA opossum ICI weredetermined by employing isolated strips. Electrical field stimulation(0.2-8.0 Hz) caused frequency-dependent NANC relaxations. Nicotine and ATP also induced concentration dependent NANC relaxations that were abolished by tetrodotoxin (TTX). The relaxation response induced by NANC nerve activation was reduced in a dose dependent manner by NO synthase inhibitors while vasoactive intestinal peptide (VIP) and sodium nitroprusside (SNP) induced relaxations were uninfluenced by these drugs, in vivo, the NO synthase inhibitor, L-NAME, administered into the local artery caused a raise in intraluminal pressure of the ICJ in anaesthetized SA opossums in a L-arginine-preventable manner. Hydroquinone and pyrogallol, while being able to reduce, in a superoxide dimutase (SOD) reversible manner, the relaxations induced by exogenous NO failedto affect the NANC nerve-induced relaxations. Finally, neurones and nerve fibres in the myenteric plexus as well as varicose nerve fibres on the circular smooth layer were positive for NADPH-diaphorase activity. These findings indicate that nitrergic nerves inhibit ICJ circular smooth muscle in vitro and in vivo but cast doubts on the nemomediatorbeing the NO radical.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:28:32