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Titolo:
ESTABLISHMENT OF EFFICIENT HYDROXYLATION AT ANGULAR POSITION OF 4A-ARYL-TRANS-DECAHYDROISOQUINOLINES
Autore:
KAWAI K; KAWAMURA K; NAGASE H;
Indirizzi:
TORAY INDUSTRIES LTD,BASIC RES LABS,1111 TEBIRO KAMAKURA KANAGAWA 248855 JAPAN
Titolo Testata:
Heterocycles
fascicolo: 5, volume: 48, anno: 1998,
pagine: 949 - 959
SICI:
0385-5414(1998)48:5<949:EOEHAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTOR ANTAGONISTS; DIFFERENTIAL ANTAGONISM; NALTRINDOLE; AGONISTS; SUBTYPES; DESIGN; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Kawai et al., "ESTABLISHMENT OF EFFICIENT HYDROXYLATION AT ANGULAR POSITION OF 4A-ARYL-TRANS-DECAHYDROISOQUINOLINES", Heterocycles, 48(5), 1998, pp. 949-959

Abstract

Efficient hydroxylation method at angular 8a position of 4a-aryl-trans-decahydroisoquinolines was described. By utilizing the transformation process, syntheses of 2-methyl- and -methoxyphenyl)-6-oxo-trans-decahydroisoquinolines (13 and 17), the useful molecules as an opioid message substructure, were attained. The key step in this transformation was N-protection of enamine intermediate by 2, 2,2-trichloroethoxycarbonyl chloride and subsequent epoxidation and hydride reduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:00:32