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Titolo:
UROKINASE RECEPTOR GENOTYPES IN COLORECTAL-CANCER
Autore:
KOHONENCORISH M; YOUNG J; CHENEVIXTRENCH G; DOE WF;
Indirizzi:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV MOL MED,GPO BOX 334 CANBERRA ACT 2601 AUSTRALIA QUEENSLAND INST MED RES BRISBANE QLD 4006 AUSTRALIA BANCROFT CTR,GLAXO CONJOINT GASTROENTEROL LAB BRISBANE QLD AUSTRALIA
Titolo Testata:
Carcinogenesis (New York. Print)
fascicolo: 6, volume: 19, anno: 1998,
pagine: 1149 - 1151
SICI:
0143-3334(1998)19:6<1149:URGIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-TRANSCRIPTION LEVELS; COLON-CANCER; PLASMINOGEN-ACTIVATOR; EXPRESSION; CELLS; GENE; CARCINOMA; AMILORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Kohonencorish et al., "UROKINASE RECEPTOR GENOTYPES IN COLORECTAL-CANCER", Carcinogenesis (New York. Print), 19(6), 1998, pp. 1149-1151

Abstract

A previous study has reported a high frequency of rare alleles of theurokinase-type plasminogen activator receptor (uPAR) in a set of 15 colorectal cancer (CRC) cell lines. Our study investigated uPAR gene variation in 92 CRC patients and in tumour DNA from a subset of 69 patients using the PLAUR-IVS3 marker located in an intron of this gene. Theoverall distribution of the marker alleles in the patients did not differ significantly from a set of 10(5) controls. A pairwise analysis of individual allele frequencies showed, however, that the common allele 147 was significantly decreased (P = 0.027) and allele 149 was significantly increased (P = 0.033) in the patients. These results may indicate an effect of uPAR gene variation in CRC carcinogenesis and encourages further examination of this marker in an independent series of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 02:00:06