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Titolo:
BCA - AN ACTIVATION-RELATED B-CELL GENE
Autore:
GANGIPETERSON L; PETERSON SN; SHAPIRO LH; GOLDING A; CARICCHIO R; COHEN DI; MARGULIES DH; COHEN PL;
Indirizzi:
UNIV N CAROLINA,CURRICULUM GENET & MOL BIOL,DEPT MED CHAPEL HILL NC 27599 UNIV N CAROLINA,CURRICULUM GENET & MOL BIOL,DEPT MED CHAPEL HILL NC 27599 UNIV N CAROLINA,CURRICULUM GENET & MOL BIOL,DEPT MICROBIOL IMMUNOL CHAPEL HILL NC 27599 ST JUDE CHILDRENS HOSP,CURRICULUM GENET & MOL BIOL MEMPHIS TN 38105 ST JUDE CHILDRENS HOSP,DEPT PHARMACOL MEMPHIS TN 38105 ST JUDE CHILDRENS HOSP,DEPT EXPT ONCOL MEMPHIS TN 38105 JOHNS HOPKINS UNIV,SCH MED BALTIMORE MD 21205 NCI,NIH BETHESDA MD 20892 NIAID,IMMUNOL LAB BETHESDA MD 20892
Titolo Testata:
Molecular immunology
fascicolo: 1, volume: 35, anno: 1998,
pagine: 55 - 63
SICI:
0161-5890(1998)35:1<55:B-AABG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; PHOSPHORYLATED IG-ALPHA; ANTIGEN RECEPTOR; BINDING-SPECIFICITY; DOMAINS; SH2; COMPLEX; ZAP-70; SYK; ABL;
Keywords:
B LYMPHOCYTES; PROTEIN KINASES/PHOSPHATASES; SIGNAL TRANSDUCTION; CELLULAR ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L. Gangipeterson et al., "BCA - AN ACTIVATION-RELATED B-CELL GENE", Molecular immunology, 35(1), 1998, pp. 55-63

Abstract

We have identified a novel activation related B-cell gene (bca) through differential hybridization screening of a murine B cell cDNA library. The deduced amino acid sequence predicted a protein of 482 amino acids with strong sequence similarity to the SH2 and SH3 domains presentwithin the non-catalytic regions of several protein tyrosine kinases. Northern analysis of RNA from several murine B-cell lines revealed a transcript of 1.8 kb, which was not detected in T-cell and non-lymphoid cell lines, bca was transcribed at low levels in resting spleen cells from a variety of normal mouse strains and was strongly expressed inkidney RNA. bca expression was markedly increased in RNA prepared from mitogen activated B cells, and in freshly isolated spleen and lymph node cells of MRL/lpr and NZB autoimmune strains. The unique sequence of bca, which bears no obvious similarity to any specific class of proteins containing SH2 and SH3 domains, suggests that this gene encodes a novel protein potentially involved in B-cell signal transduction. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 02/10/20 alle ore 01:42:55