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Titolo:
PLATELET SEROTONIN TRANSPORTER DENSITY AND RELATED PARAMETERS IN ENDURANCE-TRAINED AND SEDENTARY MALE-SUBJECTS
Autore:
STRACHAN AT; MAUGHAN RJ;
Indirizzi:
UNIV ABERDEEN,SCH MED,DEPT BIOMED SCI,FORESTERHILL ABERDEEN AB25 2ZD SCOTLAND ABERDEEN ROYAL HOSP TRUST,DEPT CLIN BIOCHEM ABERDEEN SCOTLAND UNIV ABERDEEN,SCH MED,DEPT ENVIRONM & OCCUPAT MED ABERDEEN SCOTLAND
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 2, volume: 163, anno: 1998,
pagine: 165 - 171
SICI:
0001-6772(1998)163:2<165:PSTDAR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; PLASMA-FREE TRYPTOPHAN; MESSENGER-RNA LEVELS; CHAIN AMINO-ACIDS; 5-HT UPTAKE SITES; DEPRESSED-PATIENTS; H-3-IMIPRAMINE BINDING; BRAIN TRYPTOPHAN; CHORIOCARCINOMA CELLS; PROLONGED EXERCISE;
Keywords:
ENDURANCE-TRAINED; PLATELET; SEROTONIN TRANSPORTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A.T. Strachan e R.J. Maughan, "PLATELET SEROTONIN TRANSPORTER DENSITY AND RELATED PARAMETERS IN ENDURANCE-TRAINED AND SEDENTARY MALE-SUBJECTS", Acta Physiologica Scandinavica, 163(2), 1998, pp. 165-171

Abstract

A number of peripheral indices of serotonergic function were examinedin endurance-trained (ET) and sedentary males using the blood platelet as a model of the serotonergic neurone. The aim of the study was to investigate possible involvement and adaptation of the central serotonergic system in exercise-induced fatigue. The [H-3] paroxetine-defineddensity of platelet serotonin transporters, platelet serotonin content and the plasma concentration of amino acids were determined in 10 ETand eight sedentary males. The mean (standard deviation) density oi the serotonin transporter in the platelet membranes of the ET subjects was greater [1237 (182) fmol mg protein(-1)] than that of the sedentary subjects [910 (119) fmol mg protein(-1); P = 0.013]. No difference (P = 0.51) could be seen between the median (range) platelet serotonin content of the ET subjects [0.98 (0.37-3.04) nmol platelet(-10)] and that of the sedentary subjects [0.82 (0.18-1.49) nmol platelet(-10)]. The platelet poor plasma concentrations oi tryptophan and tyrosine werelower in the ET subjects (P = 0.028 and 0.015, respectively). The present study suggests that the platelet membrane of the ET subjects has a greater density of the serotonin transporter and that this is inversely related to the circulating concentration of the serotonin precursor, tryptophan. it remains to be resolved whether the increase in serotonin transporter density in the platelet membrane of ET subjects is reflected centrally and whether the ET platelet population may be sufficiently different from that oi sedentary individuals to alter serotonintransporter density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:12:29