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Titolo:
IL-4 AND IL-13 DOWN-REGULATE ROLLING ADHESION OF LEUKOCYTES TO IL-1 OR TNF-ALPHA-ACTIVATED ENDOTHELIAL-CELLS BY LIMITING THE INTERVAL OF E-SELECTIN EXPRESSION
Autore:
ETTER H; ALTHAUS R; EUGSTER HP; SANTAMARIABABI LF; WEBER L; MOSER R;
Indirizzi:
IBR INC,POB 164 CH-9545 WAENGI SWITZERLAND ETH ZURICH,INST TOXICOL CH-8603 SCHWERZENBACH SWITZERLAND UNIV ZURICH CH-8603 SCHWERZENBACH SWITZERLAND LABS ALMIRALL SA,RES CTR BARCELONA SPAIN
Titolo Testata:
Cytokine (Philadelphia, Pa. Print)
fascicolo: 6, volume: 10, anno: 1998,
pagine: 395 - 403
SICI:
1043-4666(1998)10:6<395:IAIDRA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HOMING T-CELLS; IFN-GAMMA; MOLECULE-1 ELAM-1; SKIN; NEUTROPHILS; LYMPHOCYTES; RECEPTOR; FLOW; RECOGNITION;
Keywords:
CLA; E-SELECTIN; IL-4; IL-13; NEUTROPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
H. Etter et al., "IL-4 AND IL-13 DOWN-REGULATE ROLLING ADHESION OF LEUKOCYTES TO IL-1 OR TNF-ALPHA-ACTIVATED ENDOTHELIAL-CELLS BY LIMITING THE INTERVAL OF E-SELECTIN EXPRESSION", Cytokine (Philadelphia, Pa. Print), 10(6), 1998, pp. 395-403

Abstract

Leukocyte extravasation is governed by the endothelium, expressing a defined pattern of adhesion molecules in response to inflammatory stimuli. Among them, E-selectin, which is expressed in response to interleukin 1 (IL-1) or tumour necrosis factor alpha (TNF-alpha), provides rolling adhesion of the circulating leukocytes, a transient and reversible interaction that initiates leukocyte extravasation. In our experiments, E-selectin expression culminated after 4 to 6 h and declined thereafter. After 24 h a considerable amount of E-selectin was presented, reflecting its continuous expression in different inflammatory skin disorders. After preincubation of the endothelial cells with TNF-alpha together with IL-4 or IL-13, E-selectin mRNA transcription and protein expression were markedly reduced at 8 h and almost abolished at 20 h, In contrast, early E-selectin expression between 2 to 6 h was not significantly impaired. In a rotating adherence assay that mimics physiological shear forces in circulation, preincubation of the endothelial cells with TNF-alpha for 4 and 20 h induced similar adherence of neutrophils, which was largely E-selectin dependent. According to the modified expression kinetics of E-selectin in the presence of IL-4 or IL-13 rolling adhesion was unimpaired at 4 h but significantly diminished after 20 h of preincubation, Similar results were obtained with clones ofthe cutaneous T cell lymphoma cell line HUT78 highly expressing the E-selectin hgand cutaneous lymphocyte-associated Ag. Together, these data suggest that IL-4 and IL-13 control the rolling adhesion by limiting the period of the induced E-selectin expression and may thereby confine the acute phase of leukocyte emigration. (C) 1998 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:11:00