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Titolo:
THE C-TERMINAL DOMAIN OF SIN1 INTERACTS WITH THE SWI-SNF COMPLEX IN YEAST
Autore:
PEREZMARTIN J; JOHNSON AD;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,513 PARNASSUS,ROOM HSE401,BOX 0414 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS SAN FRANCISCO CA 94143
Titolo Testata:
Molecular and cellular biology
fascicolo: 7, volume: 18, anno: 1998,
pagine: 4157 - 4164
SICI:
0270-7306(1998)18:7<4157:TCDOSI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; HO-GENE; NEGATIVE REGULATOR; SWI/SNF COMPLEX; DNA-BINDING; TRANSCRIPTIONAL ACTIVATORS; PROTEIN; EXPRESSION; HMG1; SPT2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J. Perezmartin e A.D. Johnson, "THE C-TERMINAL DOMAIN OF SIN1 INTERACTS WITH THE SWI-SNF COMPLEX IN YEAST", Molecular and cellular biology, 18(7), 1998, pp. 4157-4164

Abstract

In the yeast Saccharomyces cerevisiae, the SWI-SNF complex has been proposed to antagonize the repressive effects of chromatin by disrupting nucleosomes. The SIN genes were identified as suppressors of defectsin the SWI-SNF complex; and the SIN1 gene encodes an HMG1-like protein that has been proposed to be a component of chromatin. Specific mutations (sin mutations) in both histone H3 and H4 genes produce the samephenotypic effects as do mutations in the SIN1 gene. In this study, we demonstrate that Sin1 and the H3 and H4 histones interact genetically and that the C terminus of Sin1 physically associates with components of the SWI-SNF complex. In addition, we demonstrate that this interaction is blocked in the full-length Sin1 protein by the N-terminal half of the protein. Based on these and additional results, we propose that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:06:51