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Titolo:
QUANTITATIVE ASSESSMENT OF MAGNETIC-RESONANCE-IMAGING LESION LOAD IN MULTIPLE-SCLEROSIS
Autore:
FILIPPI M; HORSFIELD MA; HAJNAL JV; NARAYANA PA; UDUPA JK; YOUSRY TA; ZIJDENBOS A;
Indirizzi:
UNIV MILAN,SCI INST OSPED SAN RAFFAELE,DEPT NEUROL,MS BIOSIGNAL ANAL CTR,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV LEICESTER,DIV MED PHYS LEICESTER LE1 7RH LEICS ENGLAND HAMMERSMITH HOSP,ROBERT STEINER MR UNIT,PICKER RES GRP LONDON ENGLAND UNIV TEXAS,DEPT RADIOL HOUSTON TX 00000 UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104 UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEURORADIOL D-8000 MUNICH GERMANY MCGILL UNIV,MONTREAL NEUROL INST MONTREAL PQ H3A 2T5 CANADA
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
, volume: 64, anno: 1998, supplemento:, 1
pagine: 88 - 93
SICI:
0022-3050(1998)64:<88:QAOMLL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN IMAGES; MR; REGISTRATION; SEGMENTATION; FREQUENCY; VOLUMES;
Keywords:
MULTIPLE SCLEROSIS; MAGNETIC RESONANCE IMAGING; LESION LOAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Filippi et al., "QUANTITATIVE ASSESSMENT OF MAGNETIC-RESONANCE-IMAGING LESION LOAD IN MULTIPLE-SCLEROSIS", Journal of Neurology, Neurosurgery and Psychiatry, 64, 1998, pp. 88-93

Abstract

Changes of lesion load on yearly conventional spin echo (CSE) T2-weighted scans of the brain from patients with multiple sclerosis, measured using computer assisted techniques, are used to monitor long term disease evolution, either natural or modified by treatment. Although lesion load measurements have several advantages over clinical measures of outcome (they provide a more objective and sensitive measure of disease evolution, which has a linear distribution and a more strict relation with the underlying pathology), the poor correlation between changes of lesion load and changes of disability is of concern when using such an approach for monitoring multiple sclerosis trials. In this review, the main sources of variation in T2 lesion load from brain MRT of patients with multiple sclerosis will be considered, along with possible strategies to, at least partially, overcome them. Also, some of thenewer fully automated techniques to segment multiple sclerosis lesions, which have been validated against manual outlining, and a recently developed coregistration technique are presented. It is hoped that a more reliable and standardised approach to lesion load measurements in multiple sclerosis will lead to better correlation with clinical disease course, to a higher confidence in the results of trials, and to reduced numbers of scans needed to conduct the trials, thus improving cost efficiency and reducing discomfort of the patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:04:50