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Titolo:
MOLECULAR-CLONING OF THE HUMAN P120(CTN) CATENIN GENE (CTNND1) - EXPRESSION OF MULTIPLE ALTERNATIVELY SPLICED ISOFORMS
Autore:
KEIRSEBILCK A; BONNE S; STAES K; VANHENGEL J; NOLLET F; REYNOLDS A; VANROY F;
Indirizzi:
STATE UNIV GHENT,VIB,FLANDERS INTERUNIV INST BIOTECHNOL,MOL CELL BIOLUNIT,LEDEGANCKSTR 35 B-9000 GHENT BELGIUM STATE UNIV GHENT,VIB,FLANDERS INTERUNIV INST BIOTECHNOL,MOL CELL BIOLUNIT B-9000 GHENT BELGIUM VANDERBILT UNIV,SCH MED,DEPT CELL BIOL NASHVILLE TN 37232
Titolo Testata:
Genomics
fascicolo: 2, volume: 50, anno: 1998,
pagine: 129 - 146
SICI:
0888-7543(1998)50:2<129:MOTHPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE SUBSTRATE; CELL-CELL ADHESION; TRANSCRIPTION FACTOR LEF-1; BETA-CATENIN; E-CADHERIN; ALPHA-CATENIN; DESMOSOMAL PLAQUE; TRANSFORMED CELLS; COMPLEX-FORMATION; BAND-6 PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A. Keirsebilck et al., "MOLECULAR-CLONING OF THE HUMAN P120(CTN) CATENIN GENE (CTNND1) - EXPRESSION OF MULTIPLE ALTERNATIVELY SPLICED ISOFORMS", Genomics, 50(2), 1998, pp. 129-146

Abstract

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins. Among these junctional plaque proteins are several members of the Armadillo gene family: beta-catenin,plakoglobin, and p120(ctn). Recently it became clear that some catenins also mediate nuclear signaling. We performed a detailed analysis ofthe human p120(ctn) gene (HGMW-approved symbol CTNND1) and its transcripts. The human p120(ctn) gene comprises 21 exons, potentially encoding up to 32 protein isoforms as products of alternative splicing. Human isoforms, designated 1 to 4, differ from each other by the start codon used. Additional isoforms are derived from combinations with alternatively used exons A (exon 18) and B (20), near the end of the open reading frame, and also with exon C (11) in the middle of the open reading frame. Hence, the longest isoform is of type 1ABC and comprises 968amino acid residues. The functional consequence of the observed multitude of p120(ctn) splice variants awaits further study, but tissue-specific expression was obvious. Further, we demonstrate that the exon organization, which is not simply related to the Armadillo repeat structure, is very well conserved between the p120(ctn) gene and the relatedARVCF gene, but not at all between these two genes and the beta-catenin or plakoglobin genes. The present data favor the concept that p1200(ctn) is the prototype of a subfamily of Armadillo proteins, comprising ARVCF, p0071, delta-catenin/NPRAP, and plakophilins 1 and 2, that are more related to each other than to other Armadillo proteins. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:26:06