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Titolo:
INDUCTION OF APOPTOSIS IN MURINE MACROPHAGES BY MYCOBACTERIUM-TUBERCULOSIS IS REACTIVE OXYGEN INTERMEDIATES-INDEPENDENT
Autore:
ROJAS M; BARRERA LF; GARCIA LF;
Indirizzi:
UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST,GRP INMUNOL CELULAR & INMUNOGENET MEDELLIN COLOMBIA UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST,GRP INMUNOL CELULAR & INMUNOGENET MEDELLIN COLOMBIA
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 247, anno: 1998,
pagine: 436 - 442
SICI:
0006-291X(1998)247:2<436:IOAIMM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACILLUS-CALMETTE-GUERIN; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; HUMAN-MONOCYTES; RESPIRATORY BURST; GAMMA-INTERFERON; BCG-RESISTANT; INFECTION; LIPOARABINOMANNAN; SALMONELLA;
Keywords:
REACTIVE OXYGEN INTERMEDIATES; REACTIVE NITROGEN INTERMEDIATES; NITRIC OXIDE; APOPTOSIS; NRAMP1; MURINE MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M. Rojas et al., "INDUCTION OF APOPTOSIS IN MURINE MACROPHAGES BY MYCOBACTERIUM-TUBERCULOSIS IS REACTIVE OXYGEN INTERMEDIATES-INDEPENDENT", Biochemical and biophysical research communications, 247(2), 1998, pp. 436-442

Abstract

Infection with Mycobacterium tuberculosis induces apoptosis in murinemacrophage lines. Resistant macrophages B10R (Bcg(r)) are more prone to undergo apoptosis than susceptible BIOS (Bcg(s)) macrophages. Apoptosis and inhibition of intracellular growth of the mycobacteria seem to be dependent on the production of nitric oxide, since both can be reverted by aminoguanidine (AMG). Although B10R macrophages produce moresuperoxide anion than BIOS macrophages after infection with M. tuberculosis, reactive oxygen intermediate (ROIs) scavengers did not affect uptake of H-3-uracil incorporation by the mycobacteria nor the induction of apoptosis, These results further suggest that both phenomena aredependent on the production of nitric oxide by the infected macrophages. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:30:43