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Titolo:
PREVALENCE OF VACUOLATING CYTOTOXIN PRODUCTION AND DISTRIBUTION OF DISTINCT VACA ALLELES IN HELICOBACTER-PYLORI FROM CHINA
Autore:
PAN ZJ; BERG DE; VANDERHULST RWM; SU WW; RAUDONIKIENE A; XIAO SD; DANKERT J; TYTGAT GNJ; VANDERENDE A;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT MOL MICROBIOL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL & GASTROENTEROL NL-1105 AZ AMSTERDAM NETHERLANDS SHANGHAI MED UNIV 2,SHANGHAI INST DIGEST DIS SHANGHAI PEOPLES R CHINA
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 178, anno: 1998,
pagine: 220 - 226
SICI:
0022-1899(1998)178:1<220:POVCPA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-PYLORI; STRAINS; DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
Z.J. Pan et al., "PREVALENCE OF VACUOLATING CYTOTOXIN PRODUCTION AND DISTRIBUTION OF DISTINCT VACA ALLELES IN HELICOBACTER-PYLORI FROM CHINA", The Journal of infectious diseases, 178(1), 1998, pp. 220-226

Abstract

Studies of Helicobacter pylori from the West have linked production of vacuolating cytotoxin and a particular signal sequence (sla) allele of the underlying vacA gene to peptic ulcer disease (PUD). Among Chinese H. pylori most isolates from both PUD and gastritis patients were toxigenic (35/46 and 29/35, respectively). Polymerase chain reaction and DNA sequencing showed that 95 of 96 isolates carried vacA sla alleles. Ln the mid-region, 78 of 96 isolates carried m2; 14 were m1-like but only 87% identical (DNA-level) to classical mi and were designated m1b; the other 4 were unusual hybrids (m1b-type proximal, m2-type distal). isolates with mlb and m1b-m2 alleles produced higher levels of vacuolating activity than did isolates with m2 alleles (P < .01). There was no association between any vacA allele and disease. These results suggest that the composition of H. pylori gene pools varies geographically and that other as-yet-unknown polymorphic H.pylori genes are important in PUD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 02:48:26