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Titolo:
VASOCONSTRICTION INDUCED BY ZOOXANTHELLATOXIN-B, A POLYOXYGENATED LONG-CHAIN PRODUCT FROM A MARINE ALGA
Autore:
MORIYA T; ISHIDA Y; NAKAMURA H; ASARI T; MURAI A; OHIZUMI Y;
Indirizzi:
TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT MOL BIOL,AOBA KU SENDAI MIYAGI 9808578 JAPAN TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT MOL BIOL,AOBA KU SENDAI MIYAGI 9808578 JAPAN MITSUBISHI KASEI INST LIFE SCI TOKYO 1948511 JAPAN HOKKAIDO UNIV,FAC SCI,DEPT CHEM SAPPORO HOKKAIDO 060081 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 350, anno: 1998,
pagine: 59 - 65
SICI:
0014-2999(1998)350:1<59:VIBZAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIODATE-OXIDATION PRODUCTS; RAT PHEOCHROMOCYTOMA CELLS; PIG VAS-DEFERENS; GUINEA-PIG; SYMBIOTIC DINOFLAGELLATE; INHIBITORY-ACTION; RABBIT PLATELETS; SYMBIODINIUM SP; PALYTOXIN; MAITOTOXIN;
Keywords:
ZOOXANTHELLATOXIN-B; CONTRACTION; AORTA, RABBIT; CA2+ CHANNEL; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Moriya et al., "VASOCONSTRICTION INDUCED BY ZOOXANTHELLATOXIN-B, A POLYOXYGENATED LONG-CHAIN PRODUCT FROM A MARINE ALGA", European journal of pharmacology, 350(1), 1998, pp. 59-65

Abstract

We found that zooxanthellatoxin-B from a symbiotic marine alga. Symbiodinium sp., caused a concentration-dependent contraction of the rabbit isolated aorta at concentrations of 10(-7)-10(-5) M. Verapamil (10(-6) M) and mefenamic acid (10(-5) M) significantly attenuated the contractile response to zooxanthellatoxin-B at lower concentrations (10(-7)-10(-6) M) but not at higher concentrations (3 x 10(-6) 10(-5) M). Theresponse to zooxanthellatoxin-B was partly inhibited by phentolamine (10(-6) M), whereas it was potentiated by ouabain (10(-5) M). Tetrodotoxin (10(-6) M), methysergide (10(-6) M), chlorpheniramine (10(-6) M) or indomethacin (3 x 10(-6) M), however, did not affect it. The zooxanthellatoxin-B-induced contraction was abolished by incubation in Ca2+-free solution. The contractile response increased in a concentration-dependent fashion with Ca2+ (0.03 and 10 mM) or Sr2+ (0.10 and 10 mM). After treatment with verapamil (10(-6) or 5 x 10(-6) M), the concentration-contractile response curves for Ca2+ and Sr2+ in the presence of zooxanthellatoxin-B were shifted to the right in parallel. MgCl2 (10 mM) shifted the concentration-response curve for Ca2+ more markedly than did verapamil. Zooxanthellatoxin-B increased tissue Na+ and reduced tissue K+ contents in the aorta, suggesting that zooxanthellatoxin-B increases Na+ and K+ permeability across the plasma membrane. These results suggest that the zooxanthellatoxin-B-induced contraction of the aorta is caused mainly by a direct action on smooth muscle, i.e., an increase in Ca2+ permeability that occurs at least partly through voltage-sensitive Ca2+ channels as well as through nonselective cation channels in the cell membrane of smooth muscle. (C) 1998 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:38:46