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Titolo:
AVIAN MACROPHAGE METABOLISM
Autore:
DIETERT RR; GOLEMBOSKI KA;
Indirizzi:
CORNELL UNIV,COLL VET MED,DEPT MICROBIOL & IMMUNOL ITHACA NY 14850 CORNELL UNIV,INST COMPARAT & ENVIRONM TOXICOL ITHACA NY 14850
Titolo Testata:
Poultry science
fascicolo: 7, volume: 77, anno: 1998,
pagine: 990 - 997
SICI:
0032-5791(1998)77:7<990:>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ARACHIDONIC-ACID METABOLISM; TUMOR-NECROSIS-FACTOR; L-ARGININE; ACTIVATED MACROPHAGES; PERITONEAL-MACROPHAGES; MURINE MACROPHAGES; IMMUNE-RESPONSES; VITAMIN-E; INDUCTION;
Keywords:
MACROPHAGES; REACTIVE OXYGEN SPECIES; REACTIVE NITROGEN SPECIES; EICOSANOIDS; LEUKOCYTIC MONOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Dietert e K.A. Golemboski, "AVIAN MACROPHAGE METABOLISM", Poultry science, 77(7), 1998, pp. 990-997

Abstract

This review considers the role of avian macrophages as a source of immune effector and immunoregulatory metabolites. Although considerable attention has been given to the importance of leukocytic cytokines, particularly the monokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta (TGF-beta), metabolites produced by macrophages appear to be of equal importance in determining the progression of immune responses. The three metabolite categories that have received the greatestattention are the reactive oxygen species (ROS), the reactive nitrogen intermediates (RNI), and the eicosanoids. Additionally, the xenobiotic metabolites produced via cytochrome P450 activity mediate some immune-environmental interactions. Each of these four metabolite categories is subject to different requirements for metabolite production, and each has distinct effector functions. An understanding of macrophage metabolite regulation could allow improvements in avian health management and production via the effective control of metabolite production. The present review considers prior and recent information on the production of the metabolites by avian macrophages. Additionally, the potential ramifications of metabolite production and regulation are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:19:35