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Titolo:
CEREBRAL BLOOD-FLOW AND OXYGEN-METABOLISM BEFORE AND AFTER A STROKE-LIKE EPISODE IN PATIENTS WITH MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC-ACIDOSIS AND STROKE-LIKE EPISODES (MELAS)
Autore:
TAKAHASHI S; TOHGI H; YONEZAWA H; OBARA S; NAGANE Y;
Indirizzi:
IWATE MED UNIV,DEPT NEUROL,19-1 UCHIMARU MORIOKA IWATE 020 JAPAN IWATE MED UNIV,DEPT NEUROL MORIOKA IWATE 020 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 158, anno: 1998,
pagine: 58 - 64
SICI:
0022-510X(1998)158:1<58:CBAOBA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFER RNALEU(UUR) GENE; COMPUTED-TOMOGRAPHY; ENCEPHALOMYOPATHY; MUTATION; VESSELS; BRAIN; SPECT; MRI; CT;
Keywords:
POSITRON EMISSION TOMOGRAPHY (PET); MAGNETIC RESONANCE IMAGING (MRI); CEREBRAL BLOOD FLOW; OXYGEN METABOLISM; HYPEREMIA; MITOCHONDRIAL MYOPATHY; ENCEPHALOPATHY; LACTIC ACIDOSIS AND STROKE-LIKE EPISODES (MELAS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Takahashi et al., "CEREBRAL BLOOD-FLOW AND OXYGEN-METABOLISM BEFORE AND AFTER A STROKE-LIKE EPISODE IN PATIENTS WITH MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC-ACIDOSIS AND STROKE-LIKE EPISODES (MELAS)", Journal of the neurological sciences, 158(1), 1998, pp. 58-64

Abstract

Cerebral blood flow and oxygen metabolism were examined in two patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) using positron emission tomography (PET). Regional cerebral blood flow (rCBF), regional cerebral oxygen metabolicrate (rCMRO(2)) and regional oxygen extraction fraction (roEF) were determined with the steady-state technique using oxygen-15-labeled tracers (O-15(2), (CO2)-O-15 and (CO)-O-15). Case 1, a 45-year-old woman, presented with abrupt onset of fluent aphasia. T2-weighted magnetic resonance imaging (MRI) showed a high signal intensity lesion in the left temporoparietal region. The first PET study on day 16 showed increased rCBF and decreased rCMRO(2) in the temporal region. In the second PET study, on day 35, rCBF in the temporal region had decreased. Case 2was a 19-year-old male; the second son of Case 1. He complained of transient blurring of vision, and then generalized tonic-clonic convulsion occurred. A PET study six days before this stroke-like episode demonstrated increased rCBF in both frontal lobes and putamen, where MRI showed lesions after the episode. Focal hyperemia of the lesion antedated and lasted for at least sixteen days after the stroke-like episode in these MELAS patients. These stroke-like episodes appear to be the result of metabolic dysfunction in neural tissue, although the role of an ischemic vascular event cannot be ruled out. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:28:35