Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TRANSGLUTAMINASE ACTIVITY IN SERUM AND CEREBROSPINAL-FLUID IN SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS - A POSSIBLE USE AS AN INDICATOR OF EXTENT OF THE MOTOR-NEURON LOSS
Autore:
FUJITA K; HONDA M; HAYASHI R; OGAWA K; ANDO M; YAMAUCHI M; NAGATA Y;
Indirizzi:
FUJITA HLTH UNIV,SCH MED,DEPT PHYSIOL TOYOAKE AICHI 47011 JAPAN YOKOHAMA CITY HOSP,DEPT NEUROL YOKOHAMA KANAGAWA 240 JAPAN AICHI GAKUIN UNIV,DEPT ANAT PHYSIOL OKAZAKI AICHI 444 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 158, anno: 1998,
pagine: 53 - 57
SICI:
0022-510X(1998)158:1<53:TAISAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; PROTEIN; DEGENERATION; GANGLIA; BINDING; CSF;
Keywords:
TRANSGLUTAMINASE (TGASE); CEREBROSPINAL FLUID (CSF); SERUM; SPORADIC AMYOTROPHIC LATERAL SCLEROSIS (SALS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K. Fujita et al., "TRANSGLUTAMINASE ACTIVITY IN SERUM AND CEREBROSPINAL-FLUID IN SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS - A POSSIBLE USE AS AN INDICATOR OF EXTENT OF THE MOTOR-NEURON LOSS", Journal of the neurological sciences, 158(1), 1998, pp. 53-57

Abstract

The activity of transglutaminase (TGase), a marker enzyme for tissue degeneration, was examined in serum and cerebrospinal fluid (CSF) obtained from patients with sporadic amyotrophic lateral sclerosis (SALS),and compared to those from patients without SALS. When the serum TGase activity values from SALS patients were compared against the 'ALS-scale', which is used for clinical evaluation of the progression of ALS,the TGase activity values were higher at the initial stage of the disease than in non-ALS subjects, whereas they became extremely low at the late stage of ALS. The TGase activity in the CSF taken at later thanmiddle stage from ALS patients with definite clinical motor dysfunctions was significantly lower than in that from non-ALS subjects. We have previously demonstrated marked reduction of tissue TGase activity inall regions of spinal cord tissue transections from ALS patients, notonly in ventral but also lateral and dorsal regions, relative to thatin non-ALS patients [7]. These results suggest that some TGase may beleaked out of the spinal cord tissue into the CSF and then into the blood-stream during the progression of ALS, and the enzymic activity finally becomes depleted at the terminal stages of the disease when mostof the spinal motor neuronal perikarya have been destroyed. (C) 1998 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:51:53