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Titolo:
INHIBITORY EFFECTS OF CORYMINE-RELATED COMPOUNDS ON GLYCINE RECEPTORSEXPRESSED IN XENOPUS OOCYTES
Autore:
LEEWANICH P; TOHDA M; MATSUMOTO K; SUBHADHIRASAKUL S; TAKAYAMA H; AIMI N; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PHARMACOL,2630 SUGITANI TOYAMA 9300194 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PHARMACOL TOYAMA 9300194 JAPAN PRINCE SONGKHLA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT & PHARMACOGNOSY HAT YAI 90112 SONGKHLA THAILAND CHIBA UNIV,FAC PHARMACEUT SCI CHIBA 2638522 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 2, volume: 77, anno: 1998,
pagine: 169 - 172
SICI:
0021-5198(1998)77:2<169:IEOCCO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUNTERIA-ZEYLANICA; INDOLE ALKALOIDS; THAILAND; LEAVES;
Keywords:
GLYCINE CURRENT; GAMMA-AMINOBUTYRIC ACID CURRENT; CORYMINE-RELATED COMPOUND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
P. Leewanich et al., "INHIBITORY EFFECTS OF CORYMINE-RELATED COMPOUNDS ON GLYCINE RECEPTORSEXPRESSED IN XENOPUS OOCYTES", Japanese Journal of Pharmacology, 77(2), 1998, pp. 169-172

Abstract

We examined the effects of 4 corymine-related compounds on glycine-induced chloride current in Xenopus oocytes. Dihydrocorymine, N-demethyl-3-epi-dihydrocorymine and deformylcorymine dose-dependently decreasedthe glycine current with IC50 values of 34, 37 and 55 mu M, respectively. The effect of these compounds on the glycine current was more potent than that of pleiocarpamine (IC50 > 1 mM). N-Demethyl-3-epi-dihydrocorymine and dihydrocorymine, at 100 mu M, also decreased the gamma-aminobutyric acid-induced current by 65% and 22%, respectively, whereasdeformylcorymine and pleiocarpamine failed. The inhibitory action of deformylcorymine on the glycine current was noncompetitive. These results suggest that deformylcorymine is a novel specific noncompetitive glycine receptor antagonist. The structure-activity relationship of these compounds was discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 02:00:54