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Titolo:
APOPTOSIS AND RELATED GENES IN THE RAT VENTRAL PROSTATE FOLLOWING ANDROGEN ABLATION IN RESPONSE TO ETHANE DIMETHANESULFONATE
Autore:
WOOLVERIDGE I; TAYLOR MF; WU FCW; MORRIS ID;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,DIV PHYSIOL PHARMACOL & TOXICOL,G38 STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND UNIV MANCHESTER,DEPT MED MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
The Prostate
fascicolo: 1, volume: 36, anno: 1998,
pagine: 23 - 30
SICI:
0270-4137(1998)36:1<23:AARGIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; LEYDIG-CELLS; FAS-LIGAND; MOLECULAR-CLONING; SURFACE ANTIGEN; GLANDULAR CELLS; ADULT-RAT; IN-VITRO; C-MYC; EXPRESSION;
Keywords:
EDS; P53; FAS; BCL-2; BCL-XL; BAX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
I. Woolveridge et al., "APOPTOSIS AND RELATED GENES IN THE RAT VENTRAL PROSTATE FOLLOWING ANDROGEN ABLATION IN RESPONSE TO ETHANE DIMETHANESULFONATE", The Prostate, 36(1), 1998, pp. 23-30

Abstract

BACKGROUND. Following androgen withdrawal, regression of the prostateis characterized by apoptotic cell death. The molecular events governing this process have not been fully characterized. METHODS. Using ethane-1,2-dimethanesulfonate (EDS) to induce androgen ablation, we investigated the role of the Bcl-2 family members and Fas pathway in this phenomenon. Prostates were examined from adult male rats injected with 100 mg/kg EDS and killed 2, 5, and 8 days later. RESULTS. Regression of the prostate was evident as a time-dependent decrease in weight. Thenumber of apoptotic cells identified by in situ end labeling was maximal after 5 days of treatment. There was no statistically significant change in the expression of Bar, Bcl-xl, Bcl-2, or p53 following androgen withdrawal. In contrast, 5 days post-EDS treatment, testosterone-repressed prostate message (TRPM-2) and Fas-R expression were induced. There was a decline in Fas-L levels 8 days after EDS administration. CONCLUSIONS. This study extends previous work which has shown that androgen withdrawal induces apoptosis in the prostate. We have shown that although p53 and the Bcl-2 family members examined in this study do not seem to be important in this process, the Pas pathway may play a role in apoptosis of the ventral prostate in response to androgen ablation. Prostate 36:23-30, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:20:01