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Titolo:
CORTICOTROPIN-RELEASING HORMONE (CRH)-CONTAINING NEURONS IN THE IMMATURE RAT HIPPOCAMPAL-FORMATION - LIGHT AND ELECTRON-MICROSCOPIC FEATURES AND COLOCALIZATION WITH GLUTAMATE-DECARBOXYLASE AND PARVALBUMIN
Autore:
YAN XX; TOTH Z; SCHULTZ L; RIBAK CE; BARAM TZ;
Indirizzi:
UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL IRVINE CA 92697 UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL IRVINE CA 92697 UNIV CALIF IRVINE,DEPT PEDIAT IRVINE CA 92717
Titolo Testata:
Hippocampus
fascicolo: 3, volume: 8, anno: 1998,
pagine: 231 - 243
SICI:
1050-9631(1998)8:3<231:CH(NIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DENTATE GYRUS; BINDING-PROTEIN; GENE-EXPRESSION; MESSENGER-RNA; EXTRAHYPOTHALAMIC DISTRIBUTION; GABAERGIC INNERVATION; POSTNATAL-DEVELOPMENT; STATUS EPILEPTICUS; ADENYLATE-CYCLASE;
Keywords:
HIPPOCAMPUS; INTERNEURONS; NEUROPEPTIDES; PARVALBUMIN; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
X.X. Yan et al., "CORTICOTROPIN-RELEASING HORMONE (CRH)-CONTAINING NEURONS IN THE IMMATURE RAT HIPPOCAMPAL-FORMATION - LIGHT AND ELECTRON-MICROSCOPIC FEATURES AND COLOCALIZATION WITH GLUTAMATE-DECARBOXYLASE AND PARVALBUMIN", Hippocampus, 8(3), 1998, pp. 231-243

Abstract

Corticotropin-releasing hormone (CRH) excites hippocampal neurons andinduces death of selected CA3 pyramidal cells in immature rats. Theseactions of CRH require activation of specific receptors that are abundant in CA3 during early postnatal development. Given the dramatic effects of CRH on hippocampal neurons and the absence of CRH-containing afferents to this region, we hypothesized that a significant populationof CRHergic neurons exists in developing rat hippocampus. This study defined and characterized hippocampal CRH-containing cells by using immunocytochemistry, ultrastructural examination, and colocalization with gamma-aminobutyric acid (GABA)-synthesizing enzyme and calcium-binding proteins. Numerous, large CRH-immunoreactive (ir) neurons were demonstrated in CA3 strata pyramidale and oriens, fewer were observed in the corresponding layers of CA1, and smaller CRH-ir cells were found instratum lacunosum-moleculare of Ammon's horn. In the dentate gyrus, CRH-ir somata resided in the granule cell layer and hilus. Ultrastructurally, CRH-ir neurons had aspiny dendrites and were postsynaptic to both asymmetric and symmetric synapses. CRH-ir axon terminals formed axosomatic and axodendritic symmetric synapses with pyramidal and granulecells. Other CRH-ir terminals synapsed on axon initial segments of principal neurons. Most CRH-ir neurons were coimmunolabeled for glutamate decarboxylase (GAD)-65 and GAD-67 and the majority also contained parvalbumin, but none were labeled for calbindin. These results confirm the identity of hippocampal CRH-ir cells as GABAergic interneurons. Further, a subpopulation of neurons immunoreactive for both CRH and parvalbumin and located within and adjacent to the principal cell layers consists of basket and chandelier cells. Thus, axon terminals of CRH-irinterneurons are strategically positioned to influence the excitability of the principal hippocampal neurons via release of both CRH and GABA. Hippocampus 1998;8: 231-243. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:38:57