Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A SYSTEMATIC REVIEW AND METAANALYSIS OF FAMILY HISTORY AND RISK OF OVARIAN-CANCER
Autore:
STRATTON JF; PHAROAH P; SMITH SK; EASTON D; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,WELLBEING OVARIAN CANC RES CTR,BOX 238 CAMBRIDGE CB2 2QQ ENGLAND UNIV CAMBRIDGE,INST PUBL HLTH,CRC,CANC GENET EPIDEMIOL GRP CAMBRIDGE CB2 1TN ENGLAND ROSIE MATERN HOSP,DEPT OBSTET & GYNAECOL CAMBRIDGE ENGLAND UNIV CAMBRIDGE,ACAD DEPT ONCOL CAMBRIDGE CB2 1TN ENGLAND
Titolo Testata:
British journal of obstetrics and gynaecology
fascicolo: 5, volume: 105, anno: 1998,
pagine: 493 - 499
SICI:
0306-5456(1998)105:5<493:ASRAMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-DEGREE RELATIVES; UNITED-STATES; WHITE WOMEN; BREAST; BRCA1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Stratton et al., "A SYSTEMATIC REVIEW AND METAANALYSIS OF FAMILY HISTORY AND RISK OF OVARIAN-CANCER", British journal of obstetrics and gynaecology, 105(5), 1998, pp. 493-499

Abstract

Objective To estimate the relative risk and lifetime risk of ovarian cancer in women with various categories of family history. Design A meta-analysis of all published case-control and cohort studies. Methods Pooled relative risk estimates were calculated for the case-control studies, using the Mantel- Haenzel method. These estimates were combinedwith the relative risks from the cohort studies. The pooled estimatesof relative risk were used to estimate lifetime risks of ovarian cancer from age 15 Up to age 75, for various categories of family history. Main outcome measures Relative risks and lifetime risks of developingovarian cancer were calculated for the categories of women with 1. anaffected first degree relative; 2. an affected mother; 3. an affectedsister; and 3. women with more than one affected relative. Results The relative risk to first degree relatives is 3 1 (95% CI 2.6-3.7). There is some evidence that this relative risk declines with age. The relative risk to mothers of cases 1.1 (95% CI 0.8-1.6) was lower than therelative risks to sisters: 3.8 (95% CI 2.9-5.1), and daughters: 6.0 (95% CI 3.0-11.9); the explanation of this difference is unclear. Conclusions Women with a family history of ovarian cancer have a substantially higher risk of developing ovarian cancer compared with women without such a history. However the risk is small for most categories of family history, except fbr the small number of individuals who have morethan one affected relative.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:57:27