Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FETAL HEART-RATE AND NUCHAL TRANSLUCENCY IN DETECTING CHROMOSOMAL-ABNORMALITIES OTHER THAN DOWN-SYNDROME
Autore:
MARTINEZ JM; ECHEVARRIA M; BORRELL A; PUERTO B; OJUEL J; FORTUNY A;
Indirizzi:
HOSP CLIN BARCELONA,DEPT OBSTET & GINECOL,VILLARROEL 170 BARCELONA 08036 SPAIN UNIV BARCELONA,BIOSTAT UNIT BARCELONA SPAIN HOSP & CLIN,DEPT OBSTET & GYNAECOL,PRENATAL DIAG UNIT BARCELONA 08036SPAIN
Titolo Testata:
Obstetrics and gynecology
fascicolo: 1, volume: 92, anno: 1998,
pagine: 68 - 71
SICI:
0029-7844(1998)92:1<68:FHANTI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VELOCITY WAVE-FORMS; FIRST-TRIMESTER; THICKNESS; GESTATION; FETUSES; PREGNANCIES; TRISOMY-21; DISORDERS; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Martinez et al., "FETAL HEART-RATE AND NUCHAL TRANSLUCENCY IN DETECTING CHROMOSOMAL-ABNORMALITIES OTHER THAN DOWN-SYNDROME", Obstetrics and gynecology, 92(1), 1998, pp. 68-71

Abstract

Objective: To evaluate whether the combined use of fetal heart rate (FI-ER) and nuchal translucency measurements would be useful in the prediction of fetal chromosomal abnormalities at 10-13 weeks' gestation. Methods: in a prospective study, 1053 (553 reported previously) consecutive singleton pregnancies between 10 and 13 weeks' gestation underwent chorionic villus sampling at our institution. Fetal heart rate and fetal nuchal translucency thickness were measured immediately before the invasive procedure. Results: Thirty-five abnormal karyotypes were diagnosed, including 17 trisomy 21, seven trisomy 18, one trisomy 13, one trisomy 9, four unbalanced translocation, two Klinefelter syndrome,one Turner syndrome, one deletion of chromosome 18, and one true mosaicism. Using 95% of normal ranges as the cutoff for both measurements,the detection rate for all chromosomal anomalies was 77.1%, with a false-positive rate (1-specificity) of 7.7%, a positive predictive valueof 25.7%, and a negative predictive value of 99.2%. Fetal heart rate improved the sensitivity of nuchal thickness in trisomies 21 and 18 (from 62.5% to 75%) and was particularly useful to detect other chromosomal anomalies (from 27.2% to 81.8%). Conclusion: Our findings suggest that there is an added role of FHR in ultrasound screening of chromosomal abnormalities, specifically for those other than trisomy 21 and 18. The value of a single measurement of fetal heart rate for screening purposes needs to be confirmed by further investigation in a low-risk population. (C) 1998 by The American College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:13:16