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Titolo:
ANTIGEN-SPECIFIC CYTOLYSIS BY NEUTROPHILS AND NK CELLS EXPRESSING CHIMERIC IMMUNE RECEPTORS BEARING ZETA OR GAMMA SIGNALING DOMAINS
Autore:
ROBERTS MR; COOKE KS; TRAN AC; SMITH KA; LIN WY; WANG M; DULL TJ; FARSON D; ZSEBO KM; FINER MH;
Indirizzi:
CELL GENESYS INC,342 LAKESIDE DR FOSTER CITY CA 94404
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 1, volume: 161, anno: 1998,
pagine: 375 - 384
SICI:
0022-1767(1998)161:1<375:ACBNAN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; HIGH-AFFINITY RECEPTOR; FC-EPSILON-RI; T-CELL; IGE RECEPTOR; CYTOPLASMIC DOMAIN; TYROSINE KINASES; CHAIN; SUBUNIT; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Roberts et al., "ANTIGEN-SPECIFIC CYTOLYSIS BY NEUTROPHILS AND NK CELLS EXPRESSING CHIMERIC IMMUNE RECEPTORS BEARING ZETA OR GAMMA SIGNALING DOMAINS", The Journal of immunology (1950), 161(1), 1998, pp. 375-384

Abstract

TCR-and IgG-binding Fe receptors (Fc gamma R) mediate a variety of critical biologic activities including cytolysis via the structurally related zeta- and gamma-chains, In previous studies, we have described chimeric immune receptors (CIR) in which the ligand-binding domain of aheterologous receptor or Ab is fused directly to the cytoplasmic domain of the TCR zeta-chain. Such zeta-CIRs efficiently trigger cytotoxicfunction of both T and NK cells in a target-specific manner. In this report, we compared the ability of both zeta- and zeta-CIRs to activate the cytolytic function of two distinct classes of Fc zeta R-bearing effecters, NK cells and neutrophils. Mature neutrophils expressing zeta- and gamma-CIR were generated in vivo from murine hemopoietic stem cells following transplantation of syngeneic mice with retrovirally transduced bone marrow or in vitro from transduced human CD34(+) progenitors following differentiation. Both zeta- and gamma-based CIRs were capable of activating target-specific cytolysis by both NK cells and neutrophils, although the zeta-CIR was consistently more efficient. The experimental approach described is a powerful one with which to study the role of nonlymphoid effector cells in the host immune system and permits the rational design of immunotherapeutic strategies that rely onharnessing multiple immune cell functions via CIR-modified hemopoietic stem cells or progenitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:09:32