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Titolo:
EXCITOTOXIN-INDUCED CEREBRAL HYPEREMIA IN NEWBORN PIGLETS - REGIONAL CEREBRAL BLOOD-FLOW MAPPING WITH CONTRAST-ENHANCED POWER DOPPLER US
Autore:
TAYLOR GA; BARNEWOLT CE; DUNNING PS;
Indirizzi:
CHILDRENS HOSP,DEPT RADIOL,300 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Radiology
fascicolo: 1, volume: 208, anno: 1998,
pagine: 73 - 79
SICI:
0033-8419(1998)208:1<73:ECHINP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL NEURONAL INJURY; EXCITATORY AMINO-ACIDS; ULTRASOUND; AGENT; LAMB; PERFUSION;
Keywords:
CEREBRAL BLOOD VESSELS, FLOW DYNAMICS; CEREBRAL BLOOD VESSELS, US; ULTRASOUND (US), CONTRAST MEDIA; ULTRASOUND (US), POWER DOPPLER STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Taylor et al., "EXCITOTOXIN-INDUCED CEREBRAL HYPEREMIA IN NEWBORN PIGLETS - REGIONAL CEREBRAL BLOOD-FLOW MAPPING WITH CONTRAST-ENHANCED POWER DOPPLER US", Radiology, 208(1), 1998, pp. 73-79

Abstract

PURPOSE: To create regional cerebral blood flow maps with contrast material-enhanced power Doppler ultrasound (US). MATERIALS AND METHODS: In six anesthetized newborn piglets, cerebral hyperemia was induced after intrastriatal injection of 5 mu mol of N-methyl-D-aspartic acid. Coronal power Doppler US was performed with a microbubble-based contrast agent, and cerebral blood flow was determined before and at 15, 30, and 60 minutes after injection. Images were digitized and analyzed forchanges in mean pixel intensity. A bolus injection curve was constructed by plotting mean pixel intensity versus time, and the area under this normalized curve was compared with cerebral blood flow. RESULTS: Hemispheric cerebral blood flow increased from 40 mL/min/100 g +/- 1 (mean +/- standard error) to 90 +/- 12, 86 +/- 8, 85 +/- 12 at 15, 30, and 60 minutes after injection, respectively (P < .0001 [analysis of variance]). Hemispheric mean pixel intensity at peak contrast also increased from 69 units +/- 5 to 120 +/- 4, 112 +/- 6, and 98 +/- 13 at 15,30, and 60 minutes after injection, respectively (P < .003). The areaunder the normalized curve correlated well with changes in hemispheric and striatal cerebral blood flow (r = .73, P = .0001; r = .62, P = .0001, respectively). CONCLUSION: In the newborn brain, regional blood flow maps can be created accurately with contrast-enhanced power Doppler US.

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Documento generato il 01/12/20 alle ore 16:45:54