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Titolo:
ROLE OF DOPAMINE TRANSPORTER IN METHAMPHETAMINE-INDUCED NEUROTOXICITY- EVIDENCE FROM MICE LACKING THE TRANSPORTER
Autore:
FUMAGALLI F; GAINETDINOV RR; VALENZANO KJ; CARON MG;
Indirizzi:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT CELL BIOL & MED,BOX 3287 DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT CELL BIOL & MED DURHAM NC 27710
Titolo Testata:
The Journal of neuroscience
fascicolo: 13, volume: 18, anno: 1998,
pagine: 4861 - 4869
SICI:
0270-6474(1998)18:13<4861:RODTIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE ACTIVITY; RAT-BRAIN SYNAPTOSOMES; STRIATAL DOPAMINE; IN-VIVO; TRYPTOPHAN-HYDROXYLASE; NEUROCHEMICAL RESPONSE; UPTAKE INHIBITORS; OXIDATIVE STRESS; CORPUS STRIATUM; H-3 AMPHETAMINE;
Keywords:
DOPAMINE TRANSPORTER; METHAMPHETAMINE; MICRODIALYSIS; SEROTONIN; FREE RADICAL; GFAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
F. Fumagalli et al., "ROLE OF DOPAMINE TRANSPORTER IN METHAMPHETAMINE-INDUCED NEUROTOXICITY- EVIDENCE FROM MICE LACKING THE TRANSPORTER", The Journal of neuroscience, 18(13), 1998, pp. 4861-4869

Abstract

The role of the dopamine transporter (DAT) in mediating the neurotoxic effects of methamphetamine (METH) was tested in mice lacking DAT. Dopamine (DA) and serotonin (5-HT) content, glial fibrillary acidic protein (GFAP) expression, and free radical formation were assessed as markers of METH neurotoxicity in the striatum and/or hippocampus of wild-type, heterozygote, and homozygote (DAT -/-) mice. Four injections of METH (15 mg/kg, s.c.), each given 2 hr apart, produced 80 and 30% decreases in striatal DA and 5-HT levels, respectively, in wildtype animals 2 d after administration. In addition, GFAP mRNA and protein expression levels, extracellular DA levels, and free radical formation were increased markedly. Hippocampal 5-HT content was decreased significantly as well (43%). Conversely, no significant changes were observed in total DA content, GFAP expression, extracellular DA levels, or free radical formation in the striatum of DAT -/- mice after METH administration. However, modest decreases were observed in striatal and hippocampal 5-HT levels (10 and 17%, respectively). These observations demonstrate that DAT is required for, and DA is an essential mediator of, METH-induced striatal dopaminergic neurotoxicity, whereas serotonergic deficits are only partially dependent on DAT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:10:56