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Titolo:
BIOCHEMICAL MARKERS OF BONE TURNOVER - APPLICATIONS FOR OSTEOPOROSIS
Autore:
GARNERO P; DELMAS PD;
Indirizzi:
HOP EDOUARD HERRIOT,INSERM,U403,PAVILLON F F-69437 LYON 03 FRANCE UNIV LYON 1 F-69365 LYON FRANCE
Titolo Testata:
Endocrinology and metabolism clinics of North America
fascicolo: 2, volume: 27, anno: 1998,
pagine: 303 -
SICI:
0889-8529(1998)27:2<303:BMOBT->2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT ACID-PHOSPHATASE; HORMONE REPLACEMENT THERAPY; GAMMA-CARBOXYGLUTAMIC ACID; PYRIDINIUM CROSS-LINKS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SERUM ALKALINE-PHOSPHATASE; AMINO-TERMINAL PROPEPTIDE; URINARY-EXCRETION; GLA-PROTEIN; I COLLAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
P. Garnero e P.D. Delmas, "BIOCHEMICAL MARKERS OF BONE TURNOVER - APPLICATIONS FOR OSTEOPOROSIS", Endocrinology and metabolism clinics of North America, 27(2), 1998, pp. 303

Abstract

The recent discovery of specific and sensitive biochemical markers reflecting the overall rate of bone formation and bone resorption has markedly improved the noninvasive assessment of bone turnover in variousmetabolic bone diseases, especially in osteoporosis. The immunoassay of human osteocalcin, recognizing the intact molecule and its major proteolytic fragment, and assays for bone alkaline phosphatase and the intact form of the N-terminal extension propeptide of type I collagen are currently the most sensitive markers for assessing bone formation. The l;est indices of bone resorption are the new immunoassays for pyridinoline cross-links and type I collagen-related peptides in urine and, recently, in serum. Several studies indicate that screening for these bone markers may be useful for improving the prognostic assessment of postmenopausal women in combination with bone mass measurement, thatis, their risk for osteoporosis and, ultimately, for fractures and tomonitor rapidly the efficacy of antiresorptive drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:04:53