Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ROLE OF THE ENDOTHELIUM IN CERAMIDE-INDUCED VASODILATION
Autore:
JOHNS DG; JIN JS; WEBB RC;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT PHYSIOL,7812 MED SCI BLDG 2 ANN ARBOR MI 48109 NATL DEF MED CTR,DEPT PHYSIOL TAIPEI TAIWAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 349, anno: 1998,
pagine: 9 - 10
SICI:
0014-2999(1998)349:2-3<9:TROTEI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA;
Keywords:
CERAMIDE; VASODILATION; ENDOTHELIUM; VASCULAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Johns et al., "THE ROLE OF THE ENDOTHELIUM IN CERAMIDE-INDUCED VASODILATION", European journal of pharmacology, 349(2-3), 1998, pp. 9-10

Abstract

Ceramide, a novel sphingomyelin-derived second messenger mediates cellular signals of cytokines such as tumor necrosis factor-alpha (TNF-alpha). In the present study, we hypothesized that the endothelium contributes to ceramide-induced vasodilation. We report that relaxation to ceramide in endothelium-intact rat thoracic aortic rings is greater than in endothelium-denuded or endothelial nitric oxide synthase (endothelial NO synthase)-inactivated rings. We conclude that the endotheliumcontributes to ceramide-induced relaxation possibly through an interaction between sphingomyelin hydrolysis and endothelial NO synthase within caveolae. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:29:10