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Titolo:
CLOZAPINE AND OLANZAPINE TREATMENT DECREASES RAT CORTICAL AND LIMBIC GABA(A) RECEPTORS
Autore:
FARNBACHPRALONG D; BRADBURY R; COPOLOV D; DEAN B;
Indirizzi:
MENTAL HLTH RES INST,MOL SCHIZOPHRENIA DIV,REBECCA L COOPER RES LABS,LOCKED BAG 11 PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 349, anno: 1998,
pagine: 7 - 8
SICI:
0014-2999(1998)349:2-3<7:CAOTDR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA;
Keywords:
ANTIPSYCHOTIC; GABA (GAMMA-AMINOBUTYRIC ACID); SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
D. Farnbachpralong et al., "CLOZAPINE AND OLANZAPINE TREATMENT DECREASES RAT CORTICAL AND LIMBIC GABA(A) RECEPTORS", European journal of pharmacology, 349(2-3), 1998, pp. 7-8

Abstract

The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg(-1) day-(1)) and chlorpromazine (0.1 and 1 mg kg(-1) day(-1)), clozapine and olanzapine (0.1 and 1 mg kg(-1) day(-1)) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:03:51