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Titolo:
HIGH-DOSE-RATE INTRACAVITARY IRRADIATION USING LINEAR SOURCE ARRANGEMENT FOR STAGE-II AND STAGE-III SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX
Autore:
KAGEI K; SHIRATO H; NISHIOKA T; KITAHARA T; SUZUKI K; TOMITA M; TAKAMURA A; ARIMOTO T; MATSUOKA S; MIZOE JE; SAKURAGI N; FUJIMOTO S; MIYASAKA K;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT RADIOL,KITA KU,N 15,W 7 SAPPORO HOKKAIDO 060 JAPAN NATL INST RADIOL SCI,RES CTR CHARGED PARTICLE THERAPY,DIV RADIAT MED CHIBA 260 JAPAN HOKKAIDO UNIV,SCH MED,DEPT GYNECOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Radiotherapy and oncology
fascicolo: 2, volume: 47, anno: 1998,
pagine: 207 - 213
SICI:
0167-8140(1998)47:2<207:HIIULS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; TREATMENT TIME; CANCER; BRACHYTHERAPY; RADIOTHERAPY; EXPERIENCE;
Keywords:
CARCINOMA OF THE UTERINE CERVIX; HIGH-DOSE-RATE; INTRACAVITARY IRRADIATION; LINEAR SOURCE ARRANGEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
K. Kagei et al., "HIGH-DOSE-RATE INTRACAVITARY IRRADIATION USING LINEAR SOURCE ARRANGEMENT FOR STAGE-II AND STAGE-III SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX", Radiotherapy and oncology, 47(2), 1998, pp. 207-213

Abstract

Purpose: The purpose of this article is to evaluate fractionated high-dose-rate (HDR) intracavitary irradiation using linear source arrangement (LSA) for patients with squamous cell carcinoma of the uterine cervix. Materials and methods: The subjects consisted of 217 patients (71 patients with stage II and 146 with stage III disease) who received external beam therapy (EBT) followed by fractionated HDR intracavitaryirradiation using LSA between January 1980 and June 1990. In EBT, 40 Gy in 20 fractions (40 Gy/20 Fr) or 39.6 Gy/22 Pr was delivered to thewhole pelvis and an additional 10 Gy/5 Fr or 10.8 Gy/6 Fr was delivered to the parametrium. The intracavitary irradiation dose was 30 Gy/6 Fr or 35 Gy/7 Fr with a daily fraction size of 5 Gy and two fractions per week. During the intracavitary treatment, most patients were treated on an out-patient basis. Results: Cause-specific 5-year survival rates were 77% for stage II and 50% for stage m. Pelvic failure rates were 13% for stage II and 36% for stage III. In multivariate analyses, improved cause-specific survival was significantly associated with stage II (P = 0.0003), higher pretreatment serum hemoglobin level (P = 0.0015), higher pretreatment serum total protein level (P = 0.0029), and shorter total treatment time (P = 0.0024), The rate of severe (grade 3or 4) late complication was 2% for the rectum, 1% for the small intestine or sigmoid colon and 1% for the bladder. Conclusions: Fractionated HDR intracavitary irradiation using LSA is an effective treatment for patients with uterine cervical cancer without need for hospitalization. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:36:16