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Titolo:
EFFECTS OF ETHANOL ON TEMPORAL RECOVERY OF AUDITORY-EVOKED POTENTIALSIN INDIVIDUALS AT RISK FOR ALCOHOLISM
Autore:
COHEN HL; PORJESZ B; STIMUS AT; BEGLEITER H;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PSYCHIAT,NEURODYNAM LAB,BOX 1203,450 CLARKSON AVE BROOKLYN NY 11203
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 4, volume: 22, anno: 1998,
pagine: 945 - 953
SICI:
0145-6008(1998)22:4<945:EOEOTR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; CARDIOVASCULAR REACTIVITY; EXCITABILITY CYCLE; MULTIPLE-SCLEROSIS; FAMILY HISTORY; DOSE-RESPONSE; SONS; MEN; EEG; P300;
Keywords:
LOW RISK; HIGH RISK; ALCOHOL; RECOVERY FUNCTION; AUDITORY-EVOKED POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
H.L. Cohen et al., "EFFECTS OF ETHANOL ON TEMPORAL RECOVERY OF AUDITORY-EVOKED POTENTIALSIN INDIVIDUALS AT RISK FOR ALCOHOLISM", Alcoholism, clinical and experimental research, 22(4), 1998, pp. 945-953

Abstract

The present investigation examined the effects of placebo (P), low dose (LD), and high dose (HD) ethanol on auditory event-related potential (AEP) recovery functions in a group of males at high risk to developalcoholism (HR; n = 23, mean = 22.3 years) and a low risk (LR; n = 27, mean = 23.0 years) control group. Condition order was randomized, with one condition (P, LD, or HD) per day and a minimum 1-day interval between conditions. For each subject, both blood alcohol levels (BALs) measured via breathalyzer, and event-related potentials recorded with the entire 10/20 International System, were assessed prior to and at mean intervals of 20, 60, 90, and 130 min after P, LD, or HD administration, A series of binaural auditory stimuli with randomly interposed interstimulus intervals of 0,5, 1.0, and 10.0 sec were used to elicit the N100 and P200 components of the AEP. Between-groups comparisons indicated that ethanol elicited risk group differences in recovery functions not present at baseline. The differences were manifested in the HRgroup as larger decrements in P200 amplitude during the ascending blood alcohol curve (acute sensitivity) and more rapid returns of both N100 and P200 to baseline levels during the descending blood alcohol curve (acute tolerance). These findings support Newlin and Thomson's (1990) Differentiator Model, suggesting that LR and HR individuals are differentially sensitive to the effects of ethanol.

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Documento generato il 25/01/20 alle ore 06:29:04