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Titolo:
A QUANTITATIVE TRAIT LOCUS FOR ALCOHOL-CONSUMPTION IN SELECTIVELY BRED RAT LINES
Autore:
CARR LG; FOROUD T; BICE P; GOBBETT T; IVASHINA J; EDENBERG H; LUMENG L; LI TK;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT MED,MED RES & LIB BLDG,ROOM 407,975 W WALNUT ST INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHARMACOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MED & MOL GENET INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT BIOCHEM & MOL BIOL INDIANAPOLIS IN 46202
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 4, volume: 22, anno: 1998,
pagine: 884 - 887
SICI:
0145-6008(1998)22:4<884:AQTLFA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; PREFERENCE; MICE; SENSITIVITY; ANXIETY; MODELS;
Keywords:
QUANTITATIVE TRAIT LOCUS (QTL); ALCOHOLISM RAT LINES; CHROMOSOME 4; NEUROPEPTIDE Y;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
L.G. Carr et al., "A QUANTITATIVE TRAIT LOCUS FOR ALCOHOL-CONSUMPTION IN SELECTIVELY BRED RAT LINES", Alcoholism, clinical and experimental research, 22(4), 1998, pp. 884-887

Abstract

Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lineswere inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs) influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6, This QTL acts in an additive fashion and accounts for 11% of the total phenotypic variability and approximately one-third of the genetic variability. Neuropeptide Y, an endogenous anxiolytic and neuromodulator, has been mapped to this same region of chromosome 4. This study is an advance in genome analyses, demonstrating that crosses between divergent, selectively bred rat lines can be used to identify QTLs, Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 11:27:27