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Titolo:
ASSOCIATION STUDY BETWEEN THE -141C INS DEL AND TAQI-A POLYMORPHISMS OF THE DOPAMINE D2 RECEPTOR GENE AND ALCOHOLISM/
Autore:
ISHIGURO H; ARINAMI T; SAITO T; AKAZAWA S; ENOMOTO M; MITUSHIO H; FUJISHIRO H; TADA K; AKIMOTO Y; MIFUNE H; SHIODUKA S; HAMAGUCHI H; TORU M; SHIBUYA H;
Indirizzi:
UNIV TSUKUBA,INST BASIC MED SCI,DEPT MED GENET TSUKUBA IBARAKI 305 JAPAN UNIV TSUKUBA,INST BASIC MED SCI,DEPT MED GENET TSUKUBA IBARAKI 305 JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT NEUROPSYCHIAT TOKYO 113 JAPAN SAPPORO MED UNIV SAPPORO HOKKAIDO JAPAN FUNABASHIKITA HOSP CHIBA JAPAN ENOMOTO CLIN TOKYO JAPAN TOKYO ADACHI HOSP TOKYO JAPAN BUNGOSOU HOSP IBARAKI OSAKA JAPAN RIKOKAI AKIMOTO HOSP CHIBA JAPAN HATSUISHI HOSP CHIBA JAPAN
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 4, volume: 22, anno: 1998,
pagine: 845 - 848
SICI:
0145-6008(1998)22:4<845:ASBT-I>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
A1 ALLELE; BINDING CHARACTERISTICS; SUBSTANCE-ABUSE; AL ALLELE; LINKAGE; RFLP; SCHIZOPHRENIA; POPULATION; SEROTONIN; CHILDREN;
Keywords:
ALCOHOLISM; DOPAMINE D2 RECEPTOR GENE; PROMOTER; POLYMORPHISM; JAPANESE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
H. Ishiguro et al., "ASSOCIATION STUDY BETWEEN THE -141C INS DEL AND TAQI-A POLYMORPHISMS OF THE DOPAMINE D2 RECEPTOR GENE AND ALCOHOLISM/", Alcoholism, clinical and experimental research, 22(4), 1998, pp. 845-848

Abstract

Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the -141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 Taq1 A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls (p < 0.002, odds ratio = 1.82). The Taq1 A1 allele tended to be more frequent in the alcoholics than inthe controls (p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum F value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:56:26